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mTor mechanistic Target of rapamycin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 47396, updated on 4-Jan-2025

Summary

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Official Symbol
mTorprovided by FlyBase
Official Full Name
mechanistic Target of rapamycinprovided by FlyBase
Primary source
FLYBASE:FBgn0021796
Locus tag
Dmel_CG5092
See related
AllianceGenome:FB:FBgn0021796
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
5092; CG5092; CT16317; CT24745; CT24817; Dmel\CG5092; DmTOR; dtor; dTor; dTOR; dTORC1; FRAP/TOR; l(2)k17004; mtor; mTOR; Mtor; MTOR; tor; Tor; TOR; Tor-C1; TOR-C1; Torc1; TORC1
Summary
Enables chromatin DNA binding activity and protein kinase activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; negative regulation of catabolic process; and regulation of synapse organization. Located in cytoplasm. Part of TORC1 complex and TORC2 complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See mTor in Genome Data Viewer
Location:
34A4-34A4; 2-47 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13004480..13013197)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13004480..13013197)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Yip1 domain-containing 1 Neighboring gene Vacuolar H[+] ATPase 68kD subunit 1 Neighboring gene Ubiquitination factor E4B Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inhibition of mTORC1 inhibits lytic replication of Epstein-Barr virus in a cell-type specific manner. Adamson AL, et al. Virol J, 2014 Jun 11. PMID 24917448, Free PMC Article
  2. Dendritic tiling through TOR signalling. Hong W, et al. EMBO J, 2009 Dec 16. PMID 20010972, Free PMC Article
  3. Imaging the uptake of deuterated methionine in Drosophila with stimulated Raman scattering. Spratt SJ, et al. Front Chem, 2023. PMID 37065821, Free PMC Article
  4. Roles of the insulin signaling pathway in insect development and organ growth. Lin X, et al. Peptides, 2019 Dec. PMID 29458057
  5. Target of Rapamycin Drives Unequal Responses to Essential Amino Acid Depletion for Egg Laying in Drosophila Melanogaster. Alves AN, et al. Front Cell Dev Biol, 2022. PMID 35252188, Free PMC Article

See all (730) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fat body glycolysis defects inhibit mTOR and promote distant muscle disorganization through TNF-alpha/egr and ImpL2 signaling in Drosophila larvae.
    Title: Fat body glycolysis defects inhibit mTOR and promote distant muscle disorganization through TNF-α/egr and ImpL2 signaling in Drosophila larvae.
  2. Atl (atlastin) regulates mTor signaling and autophagy in Drosophila muscle through alteration of the lysosomal network.
    Title: Atl (atlastin) regulates mTor signaling and autophagy in Drosophila muscle through alteration of the lysosomal network.
  3. Simultaneous activation of Tor and suppression of ribosome biogenesis by TRIM-NHL proteins promotes terminal differentiation.
    Title: Simultaneous activation of Tor and suppression of ribosome biogenesis by TRIM-NHL proteins promotes terminal differentiation.
  4. Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting.
    Title: Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting.
  5. Germ cells commit somatic stem cells to differentiation following priming by PI3K/Tor activity in the Drosophila testis.
    Title: Germ cells commit somatic stem cells to differentiation following priming by PI3K/Tor activity in the Drosophila testis.
  6. Ecdysone regulates Drosophila wing disc size via a TORC1 dependent mechanism.
    Title: Ecdysone regulates Drosophila wing disc size via a TORC1 dependent mechanism.
  7. FKBP39 controls nutrient dependent Nprl3 expression and TORC1 activity in Drosophila.
    Title: FKBP39 controls nutrient dependent Nprl3 expression and TORC1 activity in Drosophila.
  8. Mislocalization of TORC1 to Lysosomes Caused by KIF11 Inhibition Leads to Aberrant TORC1 Activity.
    Title: Mislocalization of TORC1 to Lysosomes Caused by KIF11 Inhibition Leads to Aberrant TORC1 Activity.
  9. Downregulation of respiratory complex I mediates major signalling changes triggered by TOR activation.
    Title: Downregulation of respiratory complex I mediates major signalling changes triggered by TOR activation.
  10. TOR signaling inhibition in intestinal stem and progenitor cells affects physiology and metabolism in Drosophila.
    Title: TOR signaling inhibition in intestinal stem and progenitor cells affects physiology and metabolism in Drosophila.
Submit: New GeneRIF Correction See all GeneRIFs (79)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISM
Inferred from Sequence Model
more info
 PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in apical protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to nutrient IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytic recycling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in germarium-derived cystoblast division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germline cell cycle switching, mitotic to meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lamellocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in larval midgut cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of proteasomal protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cell size IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cell size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of ribosome biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of synaptic assembly at neuromuscular junction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase III IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of response to drug IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of terminal button organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in terminal branching, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of TORC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC1 complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of TORC1 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of TORC2 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mechanistic target of rapamycin
Names
CG5092-PA
CG5092-PB
Target-of-rapamycin
mTOR
mTor-PA
mTor-PB
target of rapamycin
target of rapamycin complex 1
target of rapamycin kinase
NP_001260427.1
NP_524891.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13004480..13013197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273498.1 → NP_001260427.1  mechanistic target of rapamycin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260427.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H1ZYB7, H1ZYC1, M9PFS0
    Conserved Domains (6) summary
    COG5032
    Location:308 → 2471
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05169
    Location:2075 → 2353
    PIKKc_TOR; Catalytic domain of Target of Rapamycin
    pfam02260
    Location:2440 → 2471
    FATC; FATC domain
    pfam08771
    Location:1937 → 2034
    Rapamycin_bind; Rapamycin binding domain
    pfam11865
    Location:831 → 999
    DUF3385; Domain of unknown function (DUF3385)
    sd00044
    Location:632 → 658
    HEAT; HEAT repeat [structural motif]

  2. NM_080152.3 → NP_524891.1  mechanistic target of rapamycin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524891.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VK45
    UniProtKB/TrEMBL
    H1ZYB5, H1ZYB7, H1ZYC1
    Related
    FBpp0080003
    Conserved Domains (6) summary
    COG5032
    Location:347 → 2470
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05169
    Location:2074 → 2352
    PIKKc_TOR; Catalytic domain of Target of Rapamycin
    pfam02260
    Location:2439 → 2470
    FATC; FATC domain
    pfam08771
    Location:1936 → 2033
    Rapamycin_bind; Rapamycin binding domain
    pfam11865
    Location:830 → 998
    DUF3385; Domain of unknown function (DUF3385)
    sd00044
    Location:631 → 657
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PFS0 M9PFS0
Q8T9I6 Q8T9I6
Q960H0 Q960H0
Q9VK45.1 Q9VK45

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