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Reph Regulator of eph expression [ Drosophila melanogaster (fruit fly) ]

Gene ID: 47399, updated on 9-Dec-2024

Summary

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Official Symbol
Rephprovided by FlyBase
Official Full Name
Regulator of eph expressionprovided by FlyBase
Primary source
FLYBASE:FBgn0021800
Locus tag
Dmel_CG3920
See related
AllianceGenome:FB:FBgn0021800
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3920; Dmel\CG3920; l(2)k16918; reph
Summary
Involved in ephrin receptor signaling pathway and peripheral nervous system development. Located in cytoplasm. Is expressed in several structures, including central brain primordium; eye disc morphogenetic furrow; ganglia; germline cell; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Reph in Genome Data Viewer
Location:
24C5-24C5; 2-11 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3803545..3810671)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3803545..3810671)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene bark beetle Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44076

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reph, a regulator of Eph receptor expression in the Drosophila melanogaster optic lobe. Dearborn RE Jr, et al. PLoS One, 2012. PMID 22615969, Free PMC Article
  2. Swiss Cheese, a protein involved in progressive neurodegeneration, acts as a noncanonical regulatory subunit for PKA-C3. Bettencourt da Cruz A, et al. J Neurosci, 2008 Oct 22. PMID 18945896, Free PMC Article
  3. Cell-autonomous and non-autonomous growth-defective mutants of Drosophila melanogaster. Galloni M, et al. Development, 1999 Jun. PMID 10225996
  4. Functional analysis of the Drosophila embryonic germ cell transcriptome by RNA interference. Jankovics F, et al. PLoS One, 2014. PMID 24896584, Free PMC Article
  5. Seizure control through genetic and pharmacological manipulation of Pumilio in Drosophila: a key component of neuronal homeostasis. Lin WH, et al. Dis Model Mech, 2017 Feb 1. PMID 28067623, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ephrin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in peripheral nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peripheral nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 

General protein information

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Preferred Names
regulator of eph expression
Names
CG3920-PA
CG3920-PB
Reph-PA
Reph-PB
lethal (2) k16918

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    3803545..3810671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143795.4 → NP_652052.1  regulator of eph expression, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652052.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VQV2
    Related
    FBpp0077186

  2. NM_164561.3 → NP_722945.2  regulator of eph expression, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722945.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MRQ2
    Related
    FBpp0077187
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MRQ2 Q8MRQ2
Q9VQV2 Q9VQV2

Gene LinkOut

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