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Hinfp Histone H4 transcription factor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 47718, updated on 9-Dec-2024

Summary

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Official Symbol
Hinfpprovided by FlyBase
Official Full Name
Histone H4 transcription factorprovided by FlyBase
Primary source
FLYBASE:FBgn0025635
Locus tag
Dmel_CG17829
See related
AllianceGenome:FB:FBgn0025635
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17829; Dmel\CG17829; EG:115C2.6
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in gonad and organism. Orthologous to human HINFP (histone H4 transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Hinfp in Genome Data Viewer
Location:
1B12-1B12; 1-0 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (625542..628016)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (519575..522049)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Vacuolar protein sorting 37A Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45475 Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L36 Neighboring gene MYB binding protein 1a Neighboring gene Death related ced-3/Nedd2-like caspase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A cytological F1 RNAi screen for defects in Drosophila melanogaster female meiosis. Gilliland WD, et al. Genetics, 2024 May 7. PMID 38531678,
  2. Histone locus bodies: a paradigm for how nuclear biomolecular condensates control cell cycle regulated gene expression. Geisler MS, et al. Nucleus, 2023 Dec. PMID 38095604, Free PMC Article
  3. Hinfp is a guardian of the somatic genome by repressing transposable elements. Nirala NK, et al. Proc Natl Acad Sci U S A, 2021 Oct 12. PMID 34620709, Free PMC Article
  4. Identification of genes expressed during Drosophila melanogaster gastrulation by using subtractive hybridization. González-Agüero M, et al. Gene, 2005 Jan 31. PMID 15716118
  5. A Genetic Screen for Genes That Impact Peroxisomes in Drosophila Identifies Candidate Genes for Human Disease. Graves HK, et al. G3 (Bethesda), 2020 Jan 7. PMID 31767637, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
histone H4 transcription factor
Names
CG17829-PA
CG17829-PB
CG17829-PC
Hinfp-PA
Hinfp-PB
Hinfp-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    625542..628016
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143797.3 → NP_652054.1  histone H4 transcription factor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652054.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O77260
    Related
    FBpp0070111
    Conserved Domains (1) summary
    sd00017
    Location:237 → 257
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_166852.3 → NP_726685.1  histone H4 transcription factor, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726685.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W5E6
    Related
    FBpp0070112
    Conserved Domains (1) summary
    sd00017
    Location:218 → 238
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_166851.3 → NP_726684.1  histone H4 transcription factor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726684.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O77260
    Related
    FBpp0070113
    Conserved Domains (1) summary
    sd00017
    Location:237 → 257
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O77260 O77260
Q9W5E6 Q9W5E6

Gene LinkOut

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