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TTLL4A Tubulin tyrosine ligase-like 4A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 47729, updated on 4-Jan-2025

Summary

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Official Symbol
TTLL4Aprovided by FlyBase
Official Full Name
Tubulin tyrosine ligase-like 4Aprovided by FlyBase
Primary source
FLYBASE:FBgn0026147
Locus tag
Dmel_CG16833
See related
AllianceGenome:FB:FBgn0026147
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:LD13681; CG16833; DmCG16833; Dmel\CG16833; LD13681; TTLL4
Summary
Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Involved in wound healing. Predicted to be active in ciliary basal body. Orthologous to human TTLL4 (tubulin tyrosine ligase like 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See TTLL4A in Genome Data Viewer
Location:
32C1-32C1; 2-44 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10989401..10997897)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10989401..10997897)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene SCAR Neighboring gene P-element induced wimpy testis Neighboring gene uncharacterized protein Neighboring gene aubergine Neighboring gene lectin-33A Neighboring gene Ribosomal protein L9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal. Cox DN, et al. Genes Dev, 1998 Dec 1. PMID 9851978, Free PMC Article
  2. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Janke C, et al. Science, 2005 Jun 17. PMID 15890843
  3. Evolution of a genomic regulatory domain: the role of gene co-option and gene duplication in the Enhancer of split complex. Duncan EJ, et al. Genome Res, 2010 Jul. PMID 20458100, Free PMC Article
  4. Genetic screen in Drosophila melanogaster uncovers a novel set of genes required for embryonic epithelial repair. Campos I, et al. Genetics, 2010 Jan. PMID 19884309, Free PMC Article
  5. Regulation of Drosophila mesoderm migration by phosphoinositides and the PH domain of the Rho GTP exchange factor Pebble. Murray MJ, et al. Dev Biol, 2012 Dec 1. PMID 23000359

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin-glutamic acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in wound healing HMP PubMed 
Component Evidence Code Pubs
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tubulin tyrosine ligase-like 4A
Names
CG16833-PD
CG16833-PE
CG16833-PF
CG16833-PG
CG16833-PH
CG16833-PI
CG16833-PK
CG16833-PL
CG16833-PM
CG16833-PN
TTLL4A-PD
TTLL4A-PE
TTLL4A-PF
TTLL4A-PG
TTLL4A-PH
TTLL4A-PI
TTLL4A-PK
TTLL4A-PL
TTLL4A-PM
TTLL4A-PN
NP_001162946.1
NP_001162947.1
NP_001245968.1
NP_001245970.1
NP_001245971.1
NP_001245972.1
NP_001245973.1
NP_652055.2
NP_723642.2
NP_723643.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10989401..10997897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259043.2 → NP_001245972.1  tubulin tyrosine ligase-like 4A, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245972.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NCT3, Q8IGW4
    Conserved Domains (1) summary
    pfam03133
    Location:371 → 665
    TTL; Tubulin-tyrosine ligase family

  2. NM_164954.3 → NP_723643.2  tubulin tyrosine ligase-like 4A, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723643.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPB2
    Conserved Domains (1) summary
    pfam03133
    Location:614 → 908
    TTL; Tubulin-tyrosine ligase family

  3. NM_164953.3 → NP_723642.2  tubulin tyrosine ligase-like 4A, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723642.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPB2
    Conserved Domains (1) summary
    pfam03133
    Location:614 → 908
    TTL; Tubulin-tyrosine ligase family

  4. NM_143798.4 → NP_652055.2  tubulin tyrosine ligase-like 4A, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652055.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGW4, Q9VKL9
    Conserved Domains (1) summary
    pfam03133
    Location:371 → 665
    TTL; Tubulin-tyrosine ligase family

  5. NM_001169476.2 → NP_001162947.1  tubulin tyrosine ligase-like 4A, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162947.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPB2
    Conserved Domains (1) summary
    pfam03133
    Location:614 → 908
    TTL; Tubulin-tyrosine ligase family

  6. NM_001169475.2 → NP_001162946.1  tubulin tyrosine ligase-like 4A, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162946.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGW4, Q9VKL9
    Conserved Domains (1) summary
    pfam03133
    Location:371 → 665
    TTL; Tubulin-tyrosine ligase family

  7. NM_001259042.2 → NP_001245971.1  tubulin tyrosine ligase-like 4A, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245971.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NEE5
    Conserved Domains (1) summary
    pfam03133
    Location:614 → 908
    TTL; Tubulin-tyrosine ligase family

  8. NM_001259041.2 → NP_001245970.1  tubulin tyrosine ligase-like 4A, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245970.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NCT3, Q8IGW4
    Conserved Domains (1) summary
    pfam03133
    Location:371 → 665
    TTL; Tubulin-tyrosine ligase family

  9. NM_001259044.2 → NP_001245973.1  tubulin tyrosine ligase-like 4A, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245973.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NEE5
    Conserved Domains (1) summary
    pfam03133
    Location:614 → 908
    TTL; Tubulin-tyrosine ligase family

  10. NM_001259039.2 → NP_001245968.1  tubulin tyrosine ligase-like 4A, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245968.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NEE5
    Conserved Domains (1) summary
    pfam03133
    Location:614 → 908
    TTL; Tubulin-tyrosine ligase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NCT3 M9NCT3
M9NEE5 M9NEE5
Q8IGW4 Q8IGW4
Q8IPB2 Q8IPB2
Q95TA0 Q95TA0
Q9VKL9 Q9VKL9

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