U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RabGGTb Rab geranylgeranyltransferase subunit beta [ Drosophila melanogaster (fruit fly) ]

Gene ID: 47757, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
RabGGTbprovided by FlyBase
Official Full Name
Rab geranylgeranyltransferase subunit betaprovided by FlyBase
Primary source
FLYBASE:FBgn0028970
Locus tag
Dmel_CG18627
See related
AllianceGenome:FB:FBgn0028970
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
betaggt; betaggt II; betaggt-II; CG18627; Dmel\CG18627; GGT-II beta; RabGGTbeta
Summary
Contributes to Rab geranylgeranyltransferase activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Part of Rab-protein geranylgeranyltransferase complex. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; and mesoderm. Orthologous to human RABGGTB (Rab geranylgeranyltransferase subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See RabGGTb in Genome Data Viewer
Location:
23C1-23C1; 2-8 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2879112..2880708)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2879112..2880708)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Peroxiredoxin 6a Neighboring gene NTPase Neighboring gene Sabbat Neighboring gene lilliputian Neighboring gene RNA-binding protein 9 Neighboring gene Thymidylate synthase

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growth. Wittwer F, et al. Development, 2001 Mar. PMID 11171403
  2. Isoprenoids control germ cell migration downstream of HMGCoA reductase. Santos AC, et al. Dev Cell, 2004 Feb. PMID 14960281
  3. Partial inhibition of the overactivated Ku80-dependent DNA repair pathway rescues neurodegeneration in C9ORF72-ALS/FTD. Lopez-Gonzalez R, et al. Proc Natl Acad Sci U S A, 2019 May 7. PMID 31019093, Free PMC Article
  4. Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11. Charng WL, et al. PLoS Biol, 2014 Jan. PMID 24492843, Free PMC Article
  5. Use of RNA interference in Drosophila S2 cells to identify host pathways controlling compartmentalization of an intracellular pathogen. Cheng LW, et al. Proc Natl Acad Sci U S A, 2005 Sep 20. PMID 16157870, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to Rab geranylgeranyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to Rab geranylgeranyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables Rab geranylgeranyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein geranylgeranylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Rab-protein geranylgeranyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Rab-protein geranylgeranyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Rab geranylgeranyltransferase subunit beta
Names
CG18627-PA
RabGGTb-PA
beta subunit of type II geranylgeranyl transferase

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2879112..2880708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080155.3 → NP_524894.1  Rab geranylgeranyltransferase subunit beta [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524894.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XZ68
    Related
    FBpp0077316
    Conserved Domains (2) summary
    PLN03201
    Location:33 → 340
    PLN03201; RAB geranylgeranyl transferase beta-subunit; Provisional
    cd02894
    Location:29 → 315
    GGTase-II; Geranylgeranyltransferase type II (GGTase-II)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-IIs are a subgroup of the protein prenyltransferase family of lipid-modifying ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XZ68 Q9XZ68

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous