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crc - cryptocephal

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and transcription coactivator activity. Involved in several processes, including PERK-mediated unfolded protein response; instar larval or pupal development; and positive regulation of JNK cascade. Located in endoplasmic reticulum membrane. Is expressed in several structures, including LNv neurons; embryonic/larval anterior spiracle; embryonic/larval salivary gland; fat body; and ganglia. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to several human genes including ATF5 (activating transcription factor 5). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa