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vir virilizer [ Drosophila melanogaster (fruit fly) ]

Gene ID: 47869, updated on 9-Dec-2024

Summary

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Official Symbol
virprovided by FlyBase
Official Full Name
virilizerprovided by FlyBase
Primary source
FLYBASE:FBgn0003977
Locus tag
Dmel_CG3496
See related
AllianceGenome:FB:FBgn0003977
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3496; Dmel\CG3496; Vir
Summary
Involved in several processes, including positive regulation of border follicle cell migration; primary sex determination, soma; and regulation of alternative mRNA splicing, via spliceosome. Located in nucleus. Part of RNA N6-methyladenosine methyltransferase complex. Is expressed in organism. Orthologous to human VIRMA (vir like m6A methyltransferase associated). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See vir in Genome Data Viewer
Location:
59D8-59D9; 2-102 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23360192..23366355, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19247715..19253878, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44168 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Methenyltetrahydrofolate synthetase Neighboring gene Interacts with the C terminus of ELL 1 Neighboring gene Golgin-245 Neighboring gene uncharacterized protein Neighboring gene yellow-d

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein. Amrein H, et al. Cell, 1988 Dec 23. PMID 3144434
  2. Molecular identification of virilizer, a gene required for the expression of the sex-determining gene Sex-lethal in Drosophila melanogaster. Niessen M, et al. Genetics, 2001 Feb. PMID 11156988, Free PMC Article
  3. Control of oocyte maturation in sexually mature Drosophila females. Soller M, et al. Dev Biol, 1999 Apr 15. PMID 10191049
  4. virilizer regulates Sex-lethal in the germline of Drosophila melanogaster. SchüŁtt C, et al. Development, 1998 Apr. PMID 9502731
  5. The temperature-sensitive mutation vir (ts)(virilizer) identifies a new gene involved in sex determination of Drosophila. Hilfiker A, et al. Rouxs Arch Dev Biol, 1991 Nov. PMID 28305793

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing, via transesterification reactions IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in primary sex determination, soma IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 PubMed 
involved_in sex-chromosome dosage compensation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA N6-methyladenosine methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA N6-methyladenosine methyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
virilizer
Names
CG3496-PA
vir-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23360192..23366355 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080161.2 → NP_524900.1  virilizer [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524900.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W1R5
    Related
    FBpp0071946
    Conserved Domains (1) summary
    pfam15912
    Location:6 → 263
    VIR_N; Virilizer, N-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W1R5.1 Q9W1R5

Gene LinkOut

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