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mus101 mutagen-sensitive 101 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 48309, updated on 4-Jan-2025

Summary

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Official Symbol
mus101provided by FlyBase
Official Full Name
mutagen-sensitive 101provided by FlyBase
Primary source
FLYBASE:FBgn0002878
Locus tag
Dmel_CG11156
See related
AllianceGenome:FB:FBgn0002878
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0148202.1; CG11156; Dmel\CG11156; DmMus101; fs(1)K451; mus 101; mus(1)101; mus-101; Mus101; MUS101; TopBP1; TOPBP1
Summary
Involved in mitotic DNA replication checkpoint signaling. Orthologous to human TOPBP1 (DNA topoisomerase II binding protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See mus101 in Genome Data Viewer
Location:
12B4-12B4; 1-45 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13722246..13727113)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13616279..13621146)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene NAD synthetase Neighboring gene Nna1 carboxypeptidase Neighboring gene Mahogunin ring finger 1 Neighboring gene garnet Neighboring gene Gamma-tubulin ring protein 91 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutagen-sensitive mutants in Drosophila melanogaster: effects on premutational damage. Graf U, et al. Mutat Res, 1979 Nov. PMID 118370
  2. A gene controlling condensation of heterochromatin in Drosophila melanogaster. Gatti M, et al. Science, 1983 Jul 1. PMID 6407113
  3. Genetic study on the effects of the repair-deficient mutant females mei-9a, mei-41D5, mus101D1, mus104D1 and mus302D1 of Drosophila on spontaneous and X-ray-induced chromosome loss in the paternal genome. Cooper SF, et al. Mutat Res, 1981 May. PMID 6795496
  4. The C-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCA1 C Terminus (BRCT) Domain-containing Protein, Mus101, and Fidelity of DNA Segregation. Chen YT, et al. J Biol Chem, 2016 Jun 17. PMID 27129233, Free PMC Article
  5. Characterization of postreplication repair in mutagen-sensitive strains of Drosophila melanogaster. Boyd JB, et al. Genetics, 1976 Nov. PMID 826451, Free PMC Article

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila mus101 is also involved in chorion gene amplification, mostly functioning in initiation, rather than elongation.
    Title: Initiation of Drosophila chorion gene amplification requires Claspin and mus101, whereas Claspin, but not mus101, plays a major role during elongation.
  2. The Top2-Mus101 interaction is important for maintaining the fidelity of chromosome segregation during mitosis.
    Title: The C-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCA1 C Terminus (BRCT) Domain-containing Protein, Mus101, and Fidelity of DNA Segregation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic DNA replication checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mutagen-sensitive 101
Names
CG11156-PA
mus101-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    13722246..13727113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080170.4 → NP_524909.1  mutagen-sensitive 101 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524909.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YU37, Q9VY97
    Related
    FBpp0073648
    Conserved Domains (2) summary
    cd00027
    Location:1210 → 1279
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    pfam00533
    Location:707 → 778
    BRCT; BRCA1 C Terminus (BRCT) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2XXV4 Q2XXV4
Q7YU37 Q7YU37
Q9GTU6 Q9GTU6
Q9VY97 Q9VY97

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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