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Pkc53E Protein C kinase 53E [ Drosophila melanogaster (fruit fly) ]

Gene ID: 48311, updated on 4-Jan-2025

Summary

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Official Symbol
Pkc53Eprovided by FlyBase
Official Full Name
Protein C kinase 53Eprovided by FlyBase
Primary source
FLYBASE:FBgn0003091
Locus tag
Dmel_CG6622
See related
AllianceGenome:FB:FBgn0003091
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6622; Dmel\CG6622; dPKC; DPKC; Dpkc1; dPKC53E(br); pck53E; PK-C; PKC; PKC 53B; PKC 53E; PKC-53B; PKC-53E; Pkc1; PKC1; pkc53e; pkc53E; PKC53e; PKC53E
Summary
Enables protein serine/threonine kinase activity. Involved in positive regulation of clathrin-dependent endocytosis and regulation of hemocyte proliferation. Predicted to be located in plasma membrane. Is expressed in adult brain; adult head; adult mushroom body; and retina. Human ortholog(s) of this gene implicated in carcinoma (multiple); dilated cardiomyopathy; high grade glioma (multiple); ovarian cancer; and spinocerebellar ataxia type 14. Orthologous to several human genes including PRKCA (protein kinase C alpha) and PRKCB (protein kinase C beta). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Pkc53E in Genome Data Viewer
Location:
53E2-53E2; 2-81 cM
Exon count:
19
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16924655..16945126)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12812160..12832631)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mir-990 stem loop Neighboring gene inactivation no afterpotential C Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Vacuolar H[+] ATPase 16kD subunit 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure and nucleotide sequence of a Drosophila melanogaster protein kinase C gene. Rosenthal A, et al. EMBO J, 1987 Feb. PMID 3107983, Free PMC Article
  2. The cysteine-rich regions of the regulatory domains of Raf and protein kinase C as retinoid receptors. Hoyos B, et al. J Exp Med, 2000 Sep 18. PMID 10993914, Free PMC Article
  3. Inhibition of the Notch signal transducer CSL by Pkc53E-mediated phosphorylation to fend off parasitic immune challenge in Drosophila. Deichsel S, et al. Elife, 2024 Nov 6. PMID 39503739, Free PMC Article
  4. Photoreceptor deactivation and retinal degeneration mediated by a photoreceptor-specific protein kinase C. Smith DP, et al. Science, 1991 Dec 6. PMID 1962207
  5. Isolation and characterization of two new drosophila protein kinase C genes, including one specifically expressed in photoreceptor cells. Schaeffer E, et al. Cell, 1989 May 5. PMID 2720775

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A conventional PKC critical for both the light-dependent and the light-independent regulation of the actin cytoskeleton in Drosophila photoreceptors.
    Title: A conventional PKC critical for both the light-dependent and the light-independent regulation of the actin cytoskeleton in Drosophila photoreceptors.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol-dependent serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of clathrin-dependent endocytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of hemocyte proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein C kinase 53E
Names
CG6622-PA
CG6622-PB
CG6622-PC
CG6622-PD
CG6622-PE
CG6622-PF
Pkc53E-PA
Pkc53E-PB
Pkc53E-PC
Pkc53E-PD
Pkc53E-PE
Pkc53E-PF
protein kinase C
protein kinase-C 53E
protein kinase-c1
NP_001097350.1
NP_001246377.1
NP_001246378.1
NP_001261035.1
NP_476682.1
NP_725626.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16924655..16945126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274106.1 → NP_001261035.1  protein C kinase 53E, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261035.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFT3
    Conserved Domains (4) summary
    cd04026
    Location:168 → 298
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05587
    Location:344 → 663
    STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
    cd20833
    Location:44 → 101
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:111 → 164
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

  2. NM_166201.3 → NP_725626.1  protein C kinase 53E, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725626.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P05130, Q9V7V6, Q9V7V7
    Related
    FBpp0086197
    Conserved Domains (4) summary
    cd04026
    Location:177 → 307
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05587
    Location:353 → 672
    STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
    cd20833
    Location:44 → 110
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:120 → 173
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

  3. NM_001103880.3 → NP_001097350.1  protein C kinase 53E, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097350.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYG9
    Conserved Domains (4) summary
    cd04026
    Location:176 → 306
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    smart00220
    Location:349 → 607
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05587
    Location:352 → 671
    STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
    pfam00130
    Location:119 → 171
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  4. NM_001259449.1 → NP_001246378.1  protein C kinase 53E, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246378.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYG9
    Conserved Domains (4) summary
    cd04026
    Location:176 → 306
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    smart00220
    Location:349 → 607
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05587
    Location:352 → 671
    STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
    pfam00130
    Location:119 → 171
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  5. NM_057334.3 → NP_476682.1  protein C kinase 53E, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476682.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFT3
    Related
    FBpp0086198
    Conserved Domains (4) summary
    cd04026
    Location:168 → 298
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05587
    Location:344 → 663
    STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
    cd20833
    Location:44 → 101
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:111 → 164
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

  6. NM_001259448.1 → NP_001246377.1  protein C kinase 53E, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246377.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DMK5
    Conserved Domains (2) summary
    cd04026
    Location:23 → 153
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05587
    Location:199 → 518
    STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFT3 A0A0B4KFT3
A8DYG9 A8DYG9
D3DMK5 D3DMK5
P05130.2 P05130

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