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Sam-S - S-adenosylmethionine Synthetase

Predicted to enable methionine adenosyltransferase activity. Involved in S-adenosylmethionine biosynthetic process and determination of adult lifespan. Predicted to be active in cytosol. Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; gonad; gut section; and mesoderm. Used to study amino acid metabolic disorder. Human ortholog(s) of this gene implicated in hypermethioninemia and lung cancer. Orthologous to human MAT1A (methionine adenosyltransferase 1A) and MAT2A (methionine adenosyltransferase 2A). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa