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Mtr4 Mtr4 helicase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 48782, updated on 9-Dec-2024

Summary

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Official Symbol
Mtr4provided by FlyBase
Official Full Name
Mtr4 helicaseprovided by FlyBase
Primary source
FLYBASE:FBgn0001986
Locus tag
Dmel_CG4152
See related
AllianceGenome:FB:FBgn0001986
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH07290; BG:DS09217.2; br44; cg4152; CG4152; Dmel\CG4152; dMtr4; l(2)35Df; L(2)35Df; l(2)br44; l(2)k14422; l(2)k14423; l.2.35Df; lethal(2)35Df
Summary
Predicted to enable RNA helicase activity. Involved in defense response to virus. Part of catalytic step 2 spliceosome. Is expressed in adult head and organism. Orthologous to human MTREX (Mtr4 exosome RNA helicase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Mtr4 in Genome Data Viewer
Location:
35D4-35D4; 2-51 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15752263..15755900)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15752263..15755900)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) B17 subunit Neighboring gene small nuclear RNA U5 at 35D Neighboring gene Gliotactin Neighboring gene uncharacterized protein Neighboring gene weckle

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic analysis of speciation by means of introgression into Drosophila melanogaster. Sawamura K, et al. Proc Natl Acad Sci U S A, 2000 Mar 14. PMID 10706624, Free PMC Article
  2. Antisense oligonucleotide technology can be used to investigate a circular but not linear RNA-mediated function for its encoded gene locus. Song Z, et al. Sci China Life Sci, 2021 May. PMID 32815066
  3. Effects of codon usage on gene expression are promoter context dependent. Yang Q, et al. Nucleic Acids Res, 2021 Jan 25. PMID 33410890, Free PMC Article
  4. A conserved virus-induced cytoplasmic TRAMP-like complex recruits the exosome to target viral RNA for degradation. Molleston JM, et al. Genes Dev, 2016 Jul 15. PMID 27474443, Free PMC Article
  5. The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development. Furukawa T, et al. Cell, 1992 Jun 26. PMID 1617729

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in maturation of 5.8S rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of TRAMP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome HDA PubMed 

General protein information

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Preferred Names
Mtr4 helicase
Names
CG4152-PA
Mtr4-PA
lethal (2) 35Df
NP_524929.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    15752263..15755900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080190.3 → NP_524929.1  Mtr4 helicase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524929.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9Y134
    Related
    FBpp0080319
    Conserved Domains (5) summary
    COG4581
    Location:91 → 1055
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    cd00079
    Location:390 → 554
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00270
    Location:154 → 299
    DEAD; DEAD/DEAH box helicase
    pfam08148
    Location:881 → 1048
    DSHCT; DSHCT (NUC185) domain
    pfam13234
    Location:600 → 853
    rRNA_proc-arch; rRNA-processing arch domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y134 Q9Y134

Gene LinkOut

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