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Gprk2 - G protein-coupled receptor kinase 2

Enables G protein-coupled receptor kinase activity and phosphatidylinositol-4-phosphate binding activity. Involved in several processes, including oocyte morphogenesis; positive regulation of Toll signaling pathway; and regulation of smoothened signaling pathway. Located in cytoplasm and cytoplasmic side of plasma membrane. Is expressed in several structures, including central nervous system; female germline cell; imaginal disc; mushroom body; and ventral nerve cord. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in Oguchi disease-2; Parkinson's disease; congestive heart failure; essential hypertension; and night blindness. Orthologous to several human genes including GRK5 (G protein-coupled receptor kinase 5). [provided by Alliance of Genome Resources, Nov 2024]

Genes similar to Gprk2

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Species Gene Architecture aa