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Mbs Myosin binding subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 49070, updated on 4-Jan-2025

Summary

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Official Symbol
Mbsprovided by FlyBase
Official Full Name
Myosin binding subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0005536
Locus tag
Dmel_CG32156
See related
AllianceGenome:FB:FBgn0005536
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
0573/06; 0953/04; CG32156; CG5600; CG5891; DMbs; DMBS; Dmel\CG32156; DMYPT; l(3)03802; l(3)72Dd; l(3)j3B4; l(3)j7A1; l(3)S005331b; l(3)S057306; l(3)S057306b; l(3)S095304; mbs; MBS; Mypt
Summary
Predicted to enable enzyme inhibitor activity and myosin phosphatase regulator activity. Involved in several processes, including germline ring canal formation; neuron differentiation; and regulation of compound eye photoreceptor development. Located in apical cortex. Colocalizes with apical junction complex. Is expressed in several structures, including embryonic/larval esophageal visceral muscle; female germline cyst; germarium; larval muscle cell; and larval muscle system. Orthologous to several human genes including PPP1R12B (protein phosphatase 1 regulatory subunit 12B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Mbs in Genome Data Viewer
Location:
72D1-72D1; 3-44 cM
Exon count:
25
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16051959..16082026)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16045059..16075126)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45889 Neighboring gene Death-associated inhibitor of apoptosis 1 Neighboring gene long non-coding RNA:CR43951 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Taspase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Contractile and mechanical properties of epithelia with perturbed actomyosin dynamics. Fischer SC, et al. PLoS One, 2014. PMID 24759936, Free PMC Article
  2. Myosin light-chain phosphatase regulates basal actomyosin oscillations during morphogenesis. Valencia-Expósito A, et al. Nat Commun, 2016 Feb 18. PMID 26888436, Free PMC Article
  3. Structural Redundancy in Supracellular Actomyosin Networks Enables Robust Tissue Folding. Yevick HG, et al. Dev Cell, 2019 Sep 9. PMID 31353314, Free PMC Article
  4. Integration of actomyosin contractility with cell-cell adhesion during dorsal closure. Duque J, et al. Development, 2016 Dec 15. PMID 27836966
  5. Tissue Fluidity Promotes Epithelial Wound Healing. Tetley RJ, et al. Nat Phys, 2019 Jul 4. PMID 31700525, Free PMC Article

See all (131) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mbs regulates not only Myosin phosphorylation but also adhesion dynamics through control of Moesin phosphorylation, showing that Mbs coordinates actomyosin contractility with cell-cell adhesion during amnioserosa morphogenesis.
    Title: Integration of actomyosin contractility with cell-cell adhesion during dorsal closure.
  2. Par-1 binds to myosin phosphatase and phosphorylates it at a known inactivating site. Par-1 thus promotes phosphorylated myosin regulatory light chain, thereby increasing Myo-II activity.
    Title: Par-1 controls myosin-II activity through myosin phosphatase to regulate border cell migration.
  3. Mutations of DMYPT cause over constriction of contractile rings and ring canals during Drosophila germline cyst formation
    Title: Mutations of DMYPT cause over constriction of contractile rings and ring canals during Drosophila germline cyst formation.
  4. The requirement of DMBS for the integrity of static epithelial cells in imaginal discs suggests that the regulation of Myosin II by DMBS has a role more general than its previously demonstrated functions in morphogenetic events.
    Title: Essential roles of myosin phosphatase in the maintenance of epithelial cell integrity of Drosophila imaginal disc cells.
  5. required for cell sheet movement during dorsal closure, morphogenesis of the eye, and ring canal growth during oogenesis
    Title: Roles of myosin phosphatase during Drosophila development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables enzyme inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myosin phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dorsal closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epidermis development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germline ring canal formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing hair organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of compound eye photoreceptor development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with apical cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical cortex IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with apical junction complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myosin binding subunit
Names
CG32156-PE
CG32156-PF
CG32156-PG
CG32156-PH
CG32156-PI
CG32156-PJ
CG32156-PK
CG32156-PL
CG32156-PM
CG32156-PN
CG32156-PO
CG32156-PP
CG32156-PQ
CG32156-PR
CG32156-PS
CG32156-PT
CG32156-PU
CG32156-PV
MLC-phosphatase
Mbs-PE
Mbs-PF
Mbs-PG
Mbs-PH
Mbs-PI
Mbs-PJ
Mbs-PK
Mbs-PL
Mbs-PM
Mbs-PN
Mbs-PO
Mbs-PP
Mbs-PQ
Mbs-PR
Mbs-PS
Mbs-PT
Mbs-PU
Mbs-PV
lethal (3) S057306b
lethal (3) S095304
lethal(3)72Dd
myosin phosphatase
myosin phosphatase target subunit
myosin phosphatase-binding subunit
myosin-binding subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16051959..16082026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259856.2 → NP_001246785.1  myosin binding subunit, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246785.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NDS8, Q8MT32
    Conserved Domains (4) summary
    cd00204
    Location:50 → 164
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:53 → 142
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:1178 → 1244
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:78 → 109
    ANK; ANK repeat [structural motif]

  2. NM_001259857.2 → NP_001246786.1  myosin binding subunit, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246786.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NEB2, Q8MT32
    Conserved Domains (4) summary
    cd00204
    Location:50 → 164
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:53 → 142
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:1177 → 1272
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:78 → 109
    ANK; ANK repeat [structural motif]

  3. NM_001259855.2 → NP_001246784.1  myosin binding subunit, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246784.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NFF6, Q8MT32
    Conserved Domains (4) summary
    cd00204
    Location:50 → 164
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:53 → 142
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:1176 → 1242
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:78 → 109
    ANK; ANK repeat [structural motif]

  4. NM_168647.3 → NP_730100.2  myosin binding subunit, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730100.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86R99, Q9VUX6
    Conserved Domains (4) summary
    cd00204
    Location:50 → 164
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:53 → 142
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:793 → 859
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:78 → 109
    ANK; ANK repeat [structural motif]

  5. NM_001104144.3 → NP_001097614.1  myosin binding subunit, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097614.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JNT5, Q86R99
    Conserved Domains (4) summary
    cd00204
    Location:50 → 164
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:53 → 142
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:728 → 794
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:78 → 109
    ANK; ANK repeat [structural motif]

  6. NM_001104145.3 → NP_001097615.1  myosin binding subunit, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097615.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JNT4, Q86RA0
    Conserved Domains (4) summary
    cd00204
    Location:50 → 164
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:53 → 142
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:858 → 924
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:78 → 109
    ANK; ANK repeat [structural motif]

  7. NM_168646.3 → NP_730099.2  myosin binding subunit, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730099.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQN4, Q8MT32
    Conserved Domains (4) summary
    cd00204
    Location:50 → 164
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:53 → 142
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:1048 → 1143
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:78 → 109
    ANK; ANK repeat [structural motif]

  8. NM_168648.3 → NP_730101.2  myosin binding subunit, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730101.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MT32, Q8MV37
    Conserved Domains (4) summary
    cd00204
    Location:50 → 164
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:53 → 142
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:1005 → 1100
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:78 → 109
    ANK; ANK repeat [structural motif]

  9. NM_001259854.2 → NP_001246783.1  myosin binding subunit, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246783.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NDA1, Q8MT32
    Conserved Domains (4) summary
    cd00204
    Location:50 → 164
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:53 → 142
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:1134 → 1229
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:78 → 109
    ANK; ANK repeat [structural motif]

  10. NM_001259858.2 → NP_001246787.1  myosin binding subunit, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246787.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NFZ0
    Conserved Domains (3) summary
    cd00204
    Location:50 → 164
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:53 → 142
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:78 → 109
    ANK; ANK repeat [structural motif]

  11. NM_001274990.1 → NP_001261919.1  myosin binding subunit, isoform Q [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261919.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCQ3, Q8MT32
    Conserved Domains (4) summary
    cd00204
    Location:50 → 164
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:53 → 142
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:1005 → 1100
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:78 → 109
    ANK; ANK repeat [structural motif]

  12. NM_001382059.1 → NP_001369057.1  myosin binding subunit, isoform V [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6M3Q6S9, Q8MT32
    Conserved Domains (4) summary
    PHA03095
    Location:48 → 282
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:78 → 109
    ANK; ANK repeat [structural motif]
    pfam15898
    Location:1005 → 1071
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    cd21930
    Location:430 → 476
    IPD_PPP1R12; inhibitory phosphorylation domain of protein phosphatase 1 regulatory subunit 12 (PPP1R12) family

  13. NM_001382055.1 → NP_001369053.1  myosin binding subunit, isoform R [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6M3Q913
    Conserved Domains (1) summary
    pfam15898
    Location:426 → 521
    PRKG1_interact; cGMP-dependent protein kinase interacting domain

  14. NM_001382057.1 → NP_001369055.1  myosin binding subunit, isoform T [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6M3QGN9
    Conserved Domains (1) summary
    pfam15898
    Location:426 → 492
    PRKG1_interact; cGMP-dependent protein kinase interacting domain

  15. NM_001104143.3 → NP_001097613.1  myosin binding subunit, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097613.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JNT6
    Conserved Domains (1) summary
    pfam15898
    Location:271 → 366
    PRKG1_interact; cGMP-dependent protein kinase interacting domain

  16. NM_001382058.1 → NP_001369056.1  myosin binding subunit, isoform U [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6M3Q790
    Conserved Domains (1) summary
    pfam15898
    Location:271 → 337
    PRKG1_interact; cGMP-dependent protein kinase interacting domain

  17. NM_001382056.1 → NP_001369054.1  myosin binding subunit, isoform S [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6M3Q7U2
    Conserved Domains (1) summary
    pfam15898
    Location:426 → 521
    PRKG1_interact; cGMP-dependent protein kinase interacting domain

  18. NM_140573.6 → NP_648830.1  myosin binding subunit, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648830.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VUX7
    Related
    FBpp0075199
    Conserved Domains (1) summary
    pfam15898
    Location:271 → 366
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A6M3Q6S9 A0A6M3Q6S9
A0A6M3Q790 A0A6M3Q790
A0A6M3Q7U2 A0A6M3Q7U2
A0A6M3Q913 A0A6M3Q913
A0A6M3QGN9 A0A6M3QGN9
A8JNT4 A8JNT4
A8JNT5 A8JNT5
A8JNT6 A8JNT6
M9NDA1 M9NDA1
M9NDS8 M9NDS8
M9NEB2 M9NEB2
M9NFF6 M9NFF6
M9NFZ0 M9NFZ0
M9PCQ3 M9PCQ3
Q86R99 Q86R99
Q86RA0 Q86RA0
Q8IQN4 Q8IQN4
Q8MT32 Q8MT32
Q8MV37 Q8MV37
Q95SD5 Q95SD5
Q9VUX6 Q9VUX6
Q9VUX7 Q9VUX7

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