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RyR Ryanodine receptor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 49090, updated on 12-Dec-2024

Summary

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Official Symbol
RyRprovided by FlyBase
Official Full Name
Ryanodine receptorprovided by FlyBase
Primary source
FLYBASE:FBgn0011286
Locus tag
Dmel_CG10844
See related
AllianceGenome:FB:FBgn0011286
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10844; D-RyR; Dmel\CG10844; DmRyR; DRR; dry; DRY; dRyr; dRyR; dya; l(2)k00424; l(2)k04913; Rya-44F; Rya-r4; rya-r44F; Rya-r44F; Rya-R44F; Rya-r76CD; ryr; Ryr; RYR; RyRs
Summary
Enables calcium channel activity. Involved in several processes, including heart contraction; regulation of hemocyte proliferation; and response to anesthetic. Predicted to be located in membrane. Is expressed in several structures, including adult brain; adult head; adult heart; larval muscle system; and muscle cell. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including catecholaminergic polymorphic ventricular tachycardia 1; congestive heart failure (multiple); hepatocellular carcinoma; intracranial vasospasm; and muscle tissue disease (multiple). Orthologous to human RYR1 (ryanodine receptor 1); RYR2 (ryanodine receptor 2); and RYR3 (ryanodine receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See RyR in Genome Data Viewer
Location:
44F1-44F2; 2-59 cM
Exon count:
31
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8860364..8888097)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4747869..4775602)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene sticks and stones Neighboring gene uncharacterized protein Neighboring gene Dynactin 2, p50 subunit Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 genome modification in Drosophila. Douris V, et al. Insect Biochem Mol Biol, 2017 Aug. PMID 28669775
  2. Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms. Adkins AE, et al. Alcohol Clin Exp Res, 2017 May. PMID 28226201, Free PMC Article
  3. Molecular cloning of cDNA encoding a drosophila ryanodine receptor and functional studies of the carboxyl-terminal calcium release channel. Xu X, et al. Biophys J, 2000 Mar. PMID 10692315, Free PMC Article
  4. Identification of a critical region in the Drosophila ryanodine receptor that confers sensitivity to diamide insecticides. Tao Y, et al. Insect Biochem Mol Biol, 2013 Sep. PMID 23806522
  5. Multiple target-site mutations occurring in lepidopterans confer resistance to diamide insecticides. Huang 黄镜梅 JM, et al. Insect Biochem Mol Biol, 2020 Jun. PMID 32243905

See all (152) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characterization of TRPA1 and RyR demonstrates that Ca(2+) signaling is required for oxidative stress-induced activation of the Ras/MAPK pathway, which in turns drives intestinal stem cell proliferation.
    Title: Oxidative stress induces stem cell proliferation via TRPA1/RyR-mediated Ca(2+) signaling in the Drosophila midgut.
  2. The 46 aa segment of the Drosophila RyR C-terminus confers sensitivity to diamide insecticides.
    Title: Identification of a critical region in the Drosophila ryanodine receptor that confers sensitivity to diamide insecticides.
  3. Ryanodine receptors are an important mediator of immobilization by volatile anesthetics.
    Title: Drosophila ryanodine receptors mediate general anesthesia by halothane.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ryanodine-sensitive calcium-release channel activity IEA
Inferred from Electronic Annotation
more info
  
enables ryanodine-sensitive calcium-release channel activity TAS
Traceable Author Statement
more info
 PubMed 
enables store-operated calcium channel activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in heart contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of hemocyte proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in response to anesthetic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in sarcoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
ryanodine receptor
Names
CG10844-PA
CG10844-PB
CG10844-PC
CG10844-PD
CG10844-PE
CG10844-PF
CG10844-PG
CG10844-PH
CG10844-PI
CG10844-PJ
RyR-PA
RyR-PB
RyR-PC
RyR-PD
RyR-PE
RyR-PF
RyR-PG
RyR-PH
RyR-PI
RyR-PJ
RyanodineR
ryanodine receptor 44F

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8860364..8888097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259280.1 → NP_001246209.1  ryanodine receptor, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246209.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7U9
    Conserved Domains (11) summary
    smart00472
    Location:270 → 305
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    cd12877
    Location:647 → 799
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1079 → 1213
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    pfam00520
    Location:4845 → 4965
    Ion_trans; Ion transport protein
    pfam01365
    Location:443 → 636
    RYDR_ITPR; RIH domain
    pfam02026
    Location:967 → 1057
    RyR; RyR domain
    pfam02815
    Location:211 → 392
    MIR; MIR domain
    pfam06459
    Location:4514 → 4757
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:4006 → 4119
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:11 → 202
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    cd12879
    Location:1518 → 1669
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

  2. NM_001259277.1 → NP_001246206.1  ryanodine receptor, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246206.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K715
    Conserved Domains (11) summary
    smart00472
    Location:270 → 305
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    cd12877
    Location:647 → 799
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1079 → 1213
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    pfam00520
    Location:4837 → 4957
    Ion_trans; Ion transport protein
    pfam01365
    Location:443 → 636
    RYDR_ITPR; RIH domain
    pfam02026
    Location:967 → 1057
    RyR; RyR domain
    pfam02815
    Location:211 → 392
    MIR; MIR domain
    pfam06459
    Location:4506 → 4749
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:3998 → 4111
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:11 → 202
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    cd12879
    Location:1518 → 1669
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

  3. NM_057645.3 → NP_476993.1  ryanodine receptor, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476993.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24498
    Related
    FBpp0087718
    Conserved Domains (11) summary
    smart00472
    Location:270 → 305
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    cd12877
    Location:647 → 799
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1079 → 1213
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    pfam00520
    Location:4849 → 4969
    Ion_trans; Ion transport protein
    pfam01365
    Location:443 → 636
    RYDR_ITPR; RIH domain
    pfam02026
    Location:967 → 1057
    RyR; RyR domain
    pfam02815
    Location:211 → 392
    MIR; MIR domain
    pfam06459
    Location:4518 → 4761
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:4010 → 4123
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:11 → 202
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    cd12879
    Location:1518 → 1669
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

  4. NM_001259281.2 → NP_001246210.1  ryanodine receptor, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246210.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6T5
    Conserved Domains (11) summary
    smart00472
    Location:274 → 309
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    cd12877
    Location:651 → 803
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1083 → 1217
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    pfam00520
    Location:4852 → 4972
    Ion_trans; Ion transport protein
    pfam01365
    Location:447 → 640
    RYDR_ITPR; RIH domain
    pfam02026
    Location:971 → 1061
    RyR; RyR domain
    pfam02815
    Location:215 → 396
    MIR; MIR domain
    pfam06459
    Location:4521 → 4764
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:4013 → 4126
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:11 → 206
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    cd12879
    Location:1522 → 1673
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

  5. NM_001259278.2 → NP_001246207.1  ryanodine receptor, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246207.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K837
    Conserved Domains (11) summary
    smart00472
    Location:274 → 309
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    cd12877
    Location:651 → 803
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1083 → 1217
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    pfam00520
    Location:4839 → 4959
    Ion_trans; Ion transport protein
    pfam01365
    Location:447 → 640
    RYDR_ITPR; RIH domain
    pfam02026
    Location:971 → 1061
    RyR; RyR domain
    pfam02815
    Location:215 → 396
    MIR; MIR domain
    pfam06459
    Location:4508 → 4751
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:4000 → 4113
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:11 → 206
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    cd12879
    Location:1522 → 1673
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

  6. NM_057643.4 → NP_476991.1  ryanodine receptor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476991.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24321, Q24498, Q24499, Q24500, Q24501, Q8MKS3, Q8MKS4, Q8MKS5, Q9V4Y7
    Related
    FBpp0087721
    Conserved Domains (11) summary
    smart00472
    Location:270 → 305
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    cd12877
    Location:647 → 799
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1079 → 1213
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    pfam00520
    Location:4849 → 4969
    Ion_trans; Ion transport protein
    pfam01365
    Location:443 → 636
    RYDR_ITPR; RIH domain
    pfam02026
    Location:967 → 1057
    RyR; RyR domain
    pfam02815
    Location:211 → 392
    MIR; MIR domain
    pfam06459
    Location:4518 → 4761
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:4010 → 4123
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:11 → 202
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    cd12879
    Location:1518 → 1669
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

  7. NM_001259279.2 → NP_001246208.1  ryanodine receptor, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246208.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7K0
    Conserved Domains (11) summary
    smart00472
    Location:270 → 305
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    cd12877
    Location:647 → 799
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1079 → 1213
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    pfam00520
    Location:4841 → 4961
    Ion_trans; Ion transport protein
    pfam01365
    Location:443 → 636
    RYDR_ITPR; RIH domain
    pfam02026
    Location:967 → 1057
    RyR; RyR domain
    pfam02815
    Location:211 → 392
    MIR; MIR domain
    pfam06459
    Location:4510 → 4753
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:4002 → 4115
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:11 → 202
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    cd12879
    Location:1518 → 1669
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

  8. NM_057644.4 → NP_476992.1  ryanodine receptor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476992.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24498
    Related
    FBpp0087719
    Conserved Domains (11) summary
    smart00472
    Location:270 → 305
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    cd12877
    Location:647 → 799
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1079 → 1213
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    pfam00520
    Location:4835 → 4955
    Ion_trans; Ion transport protein
    pfam01365
    Location:443 → 636
    RYDR_ITPR; RIH domain
    pfam02026
    Location:967 → 1057
    RyR; RyR domain
    pfam02815
    Location:211 → 392
    MIR; MIR domain
    pfam06459
    Location:4504 → 4747
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:3996 → 4109
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:11 → 202
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    cd12879
    Location:1518 → 1669
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

  9. NM_057646.4 → NP_476994.1  ryanodine receptor, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476994.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24498
    Related
    FBpp0087720
    Conserved Domains (11) summary
    smart00472
    Location:270 → 305
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    cd12877
    Location:647 → 799
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1079 → 1213
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    pfam00520
    Location:4835 → 4955
    Ion_trans; Ion transport protein
    pfam01365
    Location:443 → 636
    RYDR_ITPR; RIH domain
    pfam02026
    Location:967 → 1057
    RyR; RyR domain
    pfam02815
    Location:211 → 392
    MIR; MIR domain
    pfam06459
    Location:4504 → 4747
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:3996 → 4109
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:11 → 202
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    cd12879
    Location:1518 → 1669
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

  10. NM_001259282.2 → NP_001246211.1  ryanodine receptor, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246211.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K719
    Conserved Domains (11) summary
    smart00472
    Location:270 → 305
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    cd12877
    Location:647 → 799
    SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
    cd12878
    Location:1079 → 1213
    SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
    pfam00520
    Location:4856 → 4976
    Ion_trans; Ion transport protein
    pfam01365
    Location:443 → 636
    RYDR_ITPR; RIH domain
    pfam02026
    Location:967 → 1057
    RyR; RyR domain
    pfam02815
    Location:211 → 392
    MIR; MIR domain
    pfam06459
    Location:4525 → 4768
    RR_TM4-6; Ryanodine Receptor TM 4-6
    pfam08454
    Location:4017 → 4130
    RIH_assoc; RyR and IP3R Homology associated
    pfam08709
    Location:11 → 202
    Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    cd12879
    Location:1518 → 1669
    SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K6T5 A0A0B4K6T5
A0A0B4K715 A0A0B4K715
A0A0B4K719 A0A0B4K719
A0A0B4K7K0 A0A0B4K7K0
A0A0B4K7U9 A0A0B4K7U9
A0A0B4K837 A0A0B4K837
Q24498.3 Q24498

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