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Phb1 Prohibitin 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 49168, updated on 4-Jan-2025

Summary

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Official Symbol
Phb1provided by FlyBase
Official Full Name
Prohibitin 1provided by FlyBase
Primary source
FLYBASE:FBgn0002031
Locus tag
Dmel_CG10691
See related
AllianceGenome:FB:FBgn0002031
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Cc; CG10691; Dmel\CG10691; fs(2)HH32; l (2) 37Cc; l(2)37Cc; l(2)Cc
Summary
Involved in cellular response to hypoxia. Located in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; epithelial cell; gut section; and larval muscle cell. Human ortholog(s) of this gene implicated in breast cancer and sporadic breast cancer. Orthologous to human PHB1 (prohibitin 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Phb1 in Genome Data Viewer
Location:
37C1-37C1; 2-54 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19121345..19123869, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19121345..19123869, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene alpha methyl dopa-resistant Neighboring gene uncharacterized protein Neighboring gene Dopa decarboxylase Neighboring gene lethal (2) 37Cb Neighboring gene lethal (2) 37Cd

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence and expression of the Cc gene, a member of the dopa decarboxylase gene cluster of Drosophila: possible translational regulation. Eveleth DD Jr, et al. Nucleic Acids Res, 1986 Aug 11. PMID 3092183, Free PMC Article
  2. Evidence for evolutionary duplication of genes in the dopa decarboxylase region of Drosophila. Eveleth DD, et al. Genetics, 1986 Oct. PMID 3021572, Free PMC Article
  3. Overlapping transcription units in Drosophila: sequence and structure of the Cs gene. Eveleth DD, et al. Mol Gen Genet, 1987 Sep. PMID 3478553
  4. Novel ability of diflubenzuron as an inhibitor of mitochondrial function. Mori K, et al. Insect Biochem Mol Biol, 2024 Apr. PMID 38342197
  5. The alpha methyl dopa hypersensitive gene, 1(2)amd, and two adjacent genes in Drosophila melanogaster: physical location and direct effects of amd on catecholamine metabolism. Black BC, et al. Mol Gen Genet, 1987 Sep. PMID 3118145

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of mitochondrial prohibitin complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
prohibitin 1
Names
CG10691-PA
CG10691-PB
CG10691-PD
Phb1-PA
Phb1-PB
Phb1-PD
lethal (2) 37Cc
transcription unit No. 4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    19121345..19123869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169541.2 → NP_001163012.2  prohibitin 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163012.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P24156, Q0E8P3, Q9VIZ4
    UniProtKB/TrEMBL
    A0A023GQA5
    Conserved Domains (1) summary
    cd03401
    Location:27 → 221
    SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  2. NM_165281.2 → NP_724165.1  prohibitin 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724165.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P24156, Q0E8P3, Q9VIZ4
    UniProtKB/TrEMBL
    A0A023GQA5
    Related
    FBpp0080708
    Conserved Domains (1) summary
    cd03401
    Location:27 → 221
    SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  3. NM_057259.6 → NP_476607.2  prohibitin 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476607.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P24156, Q0E8P3, Q9VIZ4
    UniProtKB/TrEMBL
    A0A023GQA5
    Related
    FBpp0080707
    Conserved Domains (1) summary
    cd03401
    Location:27 → 221
    SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A023GQA5 A0A023GQA5
P24156.2 P24156

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