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ctdnep1a CTD nuclear envelope phosphatase 1a [ Danio rerio (zebrafish) ]

Gene ID: 492343, updated on 4-Jan-2025

Summary

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Official Symbol
ctdnep1aprovided by ZNC
Official Full Name
CTD nuclear envelope phosphatase 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041114-177
See related
Ensembl:ENSDARG00000016519 AllianceGenome:ZFIN:ZDB-GENE-041114-177
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dullard; fi48e07; zgc:92207; im:7137489; wu:fi48e07
Summary
Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in nuclear envelope organization; positive regulation of triglyceride biosynthetic process; and protein dephosphorylation. Predicted to be located in endoplasmic reticulum membrane and nuclear membrane. Predicted to be part of Nem1-Spo7 phosphatase complex. Orthologous to human CTDNEP1 (CTD nuclear envelope phosphatase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See ctdnep1a in Genome Data Viewer
Location:
chromosome: 5
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (24047258..24056796)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (23543509..23552996)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 kinase a, polypeptide 3a Neighboring gene pyruvate dehydrogenase E1 subunit alpha 1a Neighboring gene GABA(A) receptor-associated protein a Neighboring gene G protein pathway suppressor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Comparative genomic and expression analysis of group B1 sox genes in zebrafish indicates their diversification during vertebrate evolution. Okuda Y, et al. Dev Dyn, 2006 Mar. PMID 16408288
  2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in nuclear envelope organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Nem1-Spo7 phosphatase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CTD nuclear envelope phosphatase 1A
Names
ctdnep1
dullard homolog
serine/threonine-protein phosphatase dullard-A
NP_001007310.1
XP_021331802.1
XP_068077264.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007309.1 → NP_001007310.1  CTD nuclear envelope phosphatase 1A

    See identical proteins and their annotated locations for NP_001007310.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085649
    UniProtKB/Swiss-Prot
    Q5U395, Q5U3T3
    UniProtKB/TrEMBL
    A0A8M9PK13
    Related
    ENSDARP00000036009.5, ENSDART00000029889.6
    Conserved Domains (1) summary
    TIGR02251
    Location:62 → 230
    HIF-SF_euk; Dullard-like phosphatase domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    24047258..24056796
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068221163.1 → XP_068077264.1  CTD nuclear envelope phosphatase 1A isoform X1

    UniProtKB/Swiss-Prot
    Q5U395, Q5U3T3
    UniProtKB/TrEMBL
    A0A8M9PK13

  2. XM_021476127.2 → XP_021331802.1  CTD nuclear envelope phosphatase 1A isoform X1

    UniProtKB/Swiss-Prot
    Q5U395, Q5U3T3
    UniProtKB/TrEMBL
    A0A8M9PK13
    Conserved Domains (1) summary
    TIGR02251
    Location:62 → 230
    HIF-SF_euk; Dullard-like phosphatase domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394575.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    53040..62527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U395.1 GenPept UniProtKB/Swiss-Prot:Q5U395

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