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sgms1a sphingomyelin synthase 1a [ Danio rerio (zebrafish) ]

Gene ID: 492359, updated on 4-Jan-2025

Summary

Official Symbol
sgms1aprovided by ZNC
Official Full Name
sphingomyelin synthase 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041114-201
See related
Ensembl:ENSDARG00000057053 AllianceGenome:ZFIN:ZDB-GENE-041114-201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:91976; wu:fi06d09
Summary
Predicted to enable ceramide cholinephosphotransferase activity and sphingomyelin synthase activity. Predicted to be involved in ceramide biosynthetic process and sphingomyelin biosynthetic process. Predicted to act upstream of or within apoptotic process and sphingolipid metabolic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. Orthologous to human SGMS1 (sphingomyelin synthase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See sgms1a in Genome Data Viewer
Location:
chromosome: 17
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (23729717..23765068)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (23733951..23745044)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene 3'-phosphoadenosine 5'-phosphosulfate synthase 2a Neighboring gene multiple inositol-polyphosphate phosphatase 1a Neighboring gene potassium channel, subfamily K, member 18 Neighboring gene solute carrier family 18 member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ceramide cholinephosphotransferase activity  
enables phosphotransferase activity, for other substituted phosphate groups  
enables sphingomyelin synthase activity  
enables sphingomyelin synthase activity  
enables transferase activity  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process  
involved_in ceramide biosynthetic process  
acts_upstream_of_or_within lipid metabolic process  
acts_upstream_of_or_within sphingolipid metabolic process  
involved_in sphingomyelin biosynthetic process  
Component Evidence Code Pubs
located_in Golgi apparatus  
is_active_in Golgi membrane  
is_active_in endoplasmic reticulum membrane  
located_in membrane  
is_active_in plasma membrane  

General protein information

Preferred Names
uncharacterized protein LOC492359
NP_001007326.1
XP_068070494.1
XP_068070495.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007325.2 → NP_001007326.1  uncharacterized protein LOC492359

    See identical proteins and their annotated locations for NP_001007326.1

    Status: VALIDATED

    Source sequence(s)
    CR384057
    UniProtKB/TrEMBL
    A0A8M1N376, Q5U3Z9
    Related
    ENSDARP00000144395.1, ENSDART00000179026.2
    Conserved Domains (3) summary
    cd09514
    Location:1 → 72
    SAM_SGMS1; SAM domain of sphingomyelin synthase
    smart00454
    Location:4 → 43
    SAM; Sterile alpha motif
    pfam14360
    Location:282 → 355
    PAP2_C; PAP2 superfamily C-terminal

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    23729717..23765068
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068214393.1 → XP_068070494.1  uncharacterized protein LOC492359 isoform X1

    UniProtKB/TrEMBL
    A0A8M1N376, Q5U3Z9
    Related
    ENSDARP00000031713.4, ENSDART00000034913.6
  2. XM_068214394.1 → XP_068070495.1  uncharacterized protein LOC492359 isoform X1

    UniProtKB/TrEMBL
    A0A8M1N376, Q5U3Z9

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394989.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    91861..128896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395331.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    336208..371559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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