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rec recombination-defective [ Drosophila melanogaster (fruit fly) ]

Gene ID: 49241, updated on 9-Dec-2024

Summary

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Official Symbol
recprovided by FlyBase
Official Full Name
recombination-defectiveprovided by FlyBase
Primary source
FLYBASE:FBgn0003227
Locus tag
Dmel_CG31293
See related
AllianceGenome:FB:FBgn0003227
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14875; CG31293; CG4828; Dmel\CG31293; MCM8; Rec; rec-1; rec1
Summary
Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded DNA helicase activity. Involved in reciprocal meiotic recombination. Predicted to be part of MCM complex. Predicted to be active in nucleus. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 10. Orthologous to human MCM8 (minichromosome maintenance 8 homologous recombination repair factor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See rec in Genome Data Viewer
Location:
89A5-89A5; 3-58 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15823019..15832632, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11648741..11658354, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45891 Neighboring gene alpha-Mannosidase class II b Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45211 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Time of recombination in the Drosophila melanogaster oocyte: evidence from a temperature-sensitive recombination-deficient mutant. Grell RF. Proc Natl Acad Sci U S A, 1978 Jul. PMID 98767, Free PMC Article
  2. Time of Recombination in the DROSOPHILA MELANOGASTER Oocyte. III. Selection and Characterization of Temperature-Sensitive and -Insensitive, Recombination-Deficient Alleles in Drosophila. Grell RF. Genetics, 1984 Oct. PMID 17246234, Free PMC Article
  3. The meiotic process and aneuploidy. Grell RF. Basic Life Sci, 1985. PMID 4096695
  4. Time of recombination in the Drosophila melanogaster oocyte. II. Electron microscopic and genetic studies of a temperature-sensitive recombination mutant. Grell RF, et al. Chromosoma, 1980. PMID 6778674
  5. MCM proteins in DNA replication. Tye BK. Annu Rev Biochem, 1999. PMID 10872463

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. REC drives recombination to repair double-strand breaks in animal mtDNA.
    Title: REC drives recombination to repair double-strand breaks in animal mtDNA.
  2. Mutations that disrupt REC's Walker A and B motifs differentially affect Class I and Class II crossover formation. REC may form multiple complexes that exhibit differential REC-dependent ATP-binding and -hydrolyzing requirements. These results provide genetic insight into the mechanisms through which mei-MCM proteins promote Class I crossovers and inhibit Class II crossovers.
    Title: Meiotic MCM Proteins Promote and Inhibit Crossovers During Meiotic Recombination.
  3. rec gene has no, or only a minor, role in DNA repair and recombination in somatic cells
    Title: REC, a new member of the MCM-related protein family, is required for meiotic recombination in Drosophila.
  4. REC facilitates repair synthesis during meiotic recombination
    Title: REC, Drosophila MCM8, drives formation of meiotic crossovers.
  5. Essential for DNA replication
    Title: REC, Drosophila MCM8, drives formation of meiotic crossovers.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on DNA TAS
Traceable Author Statement
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity TAS
Traceable Author Statement
more info
 PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation TAS
Traceable Author Statement
more info
 PubMed 
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
recombination-defective
Names
CG31293-PA
CG31293-PB
mini-chromosome maintenance 8
rec-PA
rec-PB
recombination defective

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15823019..15832632 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169674.2 → NP_732072.1  recombination-defective, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732072.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VF30
    UniProtKB/TrEMBL
    A0A0B4KH79, T2FGD4
    Related
    FBpp0082647
    Conserved Domains (3) summary
    smart00350
    Location:243 → 792
    MCM; minichromosome maintenance proteins
    cl09939
    Location:117 → 200
    RNR_PFL; Ribonucleotide reductase and Pyruvate formate lyase
    cl21455
    Location:468 → 606
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001275686.1 → NP_001262615.1  recombination-defective, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262615.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VF30
    UniProtKB/TrEMBL
    A0A0B4KH79, T2FGD4
    Conserved Domains (3) summary
    smart00350
    Location:243 → 792
    MCM; minichromosome maintenance proteins
    cl09939
    Location:117 → 200
    RNR_PFL; Ribonucleotide reductase and Pyruvate formate lyase
    cl21455
    Location:468 → 606
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KH79 A0A0B4KH79
Q9VF30.2 Q9VF30

Gene LinkOut

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