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SERCA - Sarco/endoplasmic reticulum Ca(2+)-ATPase

Enables P-type calcium transporter activity. Involved in several processes, including calcium ion transport from cytosol to endoplasmic reticulum; intestinal stem cell homeostasis; and stabilization of membrane potential. Located in sarcoplasmic reticulum. Is active in endoplasmic reticulum membrane. Is expressed in several structures, including adult central nervous system; embryonic/larval midgut primordium; germline cell; gut section; and muscle cell. Used to study Brody myopathy and heart disease. Human ortholog(s) of this gene implicated in Brody myopathy; acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A1 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1); ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2); and ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3). [provided by Alliance of Genome Resources, Dec 2024]

Genes similar to SERCA

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Species Gene Architecture aa