Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search NCBI

SERCA - Sarco/endoplasmic reticulum Ca(2+)-ATPase

Enables P-type calcium transporter activity. Involved in several processes, including calcium ion transport from cytosol to endoplasmic reticulum; intestinal stem cell homeostasis; and stabilization of membrane potential. Located in sarcoplasmic reticulum. Is active in endoplasmic reticulum membrane. Is expressed in several structures, including adult central nervous system; embryonic/larval midgut primordium; germline cell; gut section; and muscle cell. Used to study Brody myopathy and heart disease. Human ortholog(s) of this gene implicated in Brody myopathy; acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A1 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1); ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2); and ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3). [provided by Alliance of Genome Resources, Nov 2024]

Genes similar to SERCA

NCBI Orthologs

How was this calculated?

genes for:

Protein alignment

Align

Download data

Download
Species Gene Architecture aa