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Gsta5 glutathione S-transferase alpha 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 494499, updated on 27-Nov-2024

Summary

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Official Symbol
Gsta5provided by RGD
Official Full Name
glutathione S-transferase alpha 5provided by RGD
Primary source
RGD:1593189
See related
EnsemblRapid:ENSRNOG00000029861 AllianceGenome:RGD:1593189
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gsta2
Summary
Enables glutathione binding activity and glutathione transferase activity. Involved in xenobiotic catabolic process. Located in cytosol. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Orthologous to several human genes including GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 6559.5), Kidney (RPKM 3991.1) and 1 other tissue See more
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Genomic context

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See Gsta5 in Genome Data Viewer
Location:
8q31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (87985768..87997766)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (79105561..79117472)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (85553659..85564914)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L12, pseudogene 1 Neighboring gene glutathione S-transferase alpha 4 Neighboring gene U6 spliceosomal RNA Neighboring gene glutathione S-transferase alpha 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Construction and characterization of a plasmid containing complementary DNA to mRNA encoding the N-terminal amino acid sequence of the rat glutathione transferase Ya subunit. Taylor JB, et al. Biochem J, 1984 Apr 1. PMID 6547043, Free PMC Article
  2. Cloning and sequence analysis of a cDNA plasmid for one of the rat liver glutathione S-transferase subunits. Tu CP, et al. Nucleic Acids Res, 1982 Sep 25. PMID 6292839, Free PMC Article
  3. Expression and sequence analysis of rat liver glutathione S-transferase genes. Pickett CB, et al. Adv Exp Med Biol, 1986. PMID 3766257
  4. Structural analysis of a rat liver glutathione S-transferase Ya gene. Telakowski-Hopkins CA, et al. Proc Natl Acad Sci U S A, 1986 Dec. PMID 3025841, Free PMC Article
  5. Expression of a cDNA encoding a rat liver glutathione S-transferase Ya subunit in Escherichia coli. Wang RW, et al. Arch Biochem Biophys, 1989 Mar. PMID 2645828

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC114217

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glutathione binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in response to stilbenoid ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glutathione S-transferase alpha-2
Names
GHS transferase
GST 1b-1b
GST A2-2
GST Ya2
glutathione S-transferase Ya subunit
glutathione S-transferase Ya-2
glutathione transferase YA subunit
NP_001010921.1
XP_017451300.1
XP_017451301.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010921.2 → NP_001010921.1  glutathione S-transferase alpha-2

    See identical proteins and their annotated locations for NP_001010921.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    P04903, Q63715
    UniProtKB/TrEMBL
    A0A096MIU0, Q4FZZ3
    Related
    ENSRNOP00000043510.5, ENSRNOT00000044944.7
    Conserved Domains (3) summary
    PTZ00057
    Location:1 → 208
    PTZ00057; glutathione s-transferase; Provisional
    cd03208
    Location:86 → 220
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cd03077
    Location:4 → 82
    GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    87985768..87997766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017595811.3 → XP_017451300.1  glutathione S-transferase alpha-2 isoform X1

    UniProtKB/Swiss-Prot
    P04903, Q63715
    UniProtKB/TrEMBL
    A0A096MIU0, Q4FZZ3
    Related
    ENSRNOP00000091487.2, ENSRNOT00000106378.2
    Conserved Domains (3) summary
    PTZ00057
    Location:1 → 208
    PTZ00057; glutathione s-transferase; Provisional
    cd03208
    Location:86 → 220
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cd03077
    Location:4 → 82
    GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

  2. XM_017595812.3 → XP_017451301.1  glutathione S-transferase alpha-2 isoform X1

    UniProtKB/Swiss-Prot
    P04903, Q63715
    UniProtKB/TrEMBL
    A0A096MIU0, Q4FZZ3
    Conserved Domains (3) summary
    PTZ00057
    Location:1 → 208
    PTZ00057; glutathione s-transferase; Provisional
    cd03208
    Location:86 → 220
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cd03077
    Location:4 → 82
    GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04903.2 GenPept UniProtKB/Swiss-Prot:P04903

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