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serpind1.S serpin peptidase inhibitor, clade D (heparin cofactor), member 1 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 495373, updated on 27-Dec-2024

Summary

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Official Symbol
serpind1.S
Official Full Name
serpin peptidase inhibitor, clade D (heparin cofactor), member 1 S homeolog
Primary source
Xenbase:XB-GENE-17341844
Locus tag
XELAEV_18010524mg
See related
EnsemblRapid:ENSXLAG00005011785 AllianceGenome:Xenbase:XB-GENE-17341844
Gene type
protein coding
RefSeq status
PREDICTED
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
hcf2; hcii; hls2
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within blood coagulation. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in heparin cofactor II deficiency. Orthologous to human SERPIND1 (serpin family D member 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See serpind1.S in Genome Data Viewer
Location:
chromosome: 1S
Exon count:
5
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1S NC_054372.1 (142465874..142471523, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1S NC_030725.1 (126708864..126714514, complement)

Chromosome 1S - NC_054372.1Genomic Context describing neighboring genes Neighboring gene clathrin heavy chain like 1 S homeolog Neighboring gene synaptosome associated protein 29kDa S homeolog Neighboring gene phosphatidylinositol 4-kinase, catalytic, alpha S homeolog Neighboring gene hypermethylated in cancer 2 S homeolog Neighboring gene ubiquitin conjugating enzyme E2 L3 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood coagulation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC495373
Names
heparin cofactor II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001095035.1 → NP_001088504.1  uncharacterized protein LOC495373 precursor

    See identical proteins and their annotated locations for NP_001088504.1

    Status: PREDICTED

    Source sequence(s)
    BC099248
    UniProtKB/TrEMBL
    A0A974DUP2, Q4KLF2
    Related
    ENSXLAP00005034416.1, ENSXLAT00005035299.1
    Conserved Domains (1) summary
    cl00137
    Location:49 → 482
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    142465874..142471523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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