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OGG1 8-oxoguanine DNA glycosylase [ Homo sapiens (human) ]

Gene ID: 4968, updated on 27-Nov-2024

Summary

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Official Symbol
OGG1provided by HGNC
Official Full Name
8-oxoguanine DNA glycosylaseprovided by HGNC
Primary source
HGNC:HGNC:8125
See related
Ensembl:ENSG00000114026 MIM:601982; AllianceGenome:HGNC:8125
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HMMH; MUTM; OGH1; HOGG1
Summary
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]
Expression
Ubiquitous expression in kidney (RPKM 5.9), lymph node (RPKM 5.1) and 25 other tissues See more
Orthologs
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Genomic context

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See OGG1 in Genome Data Viewer
Location:
3p25.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (9749952..9783108)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (9741907..9758605)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (9791636..9808334)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:9745156-9746066 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:9757470-9757599 Neighboring gene copine family member 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19405 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:9772855-9773414 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14038 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14039 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:9773975-9774534 Neighboring gene bromodomain and PHD finger containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19407 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14040 Neighboring gene calcium/calmodulin dependent protein kinase I Neighboring gene Sharpr-MPRA regulatory region 4794 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14041 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:9832484-9832984 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14042 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:9834089-9834615 Neighboring gene transcriptional adaptor 3 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:9834616-9835142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19409 Neighboring gene ARPC4-TTLL3 readthrough Neighboring gene actin related protein 2/3 complex subunit 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14044 Neighboring gene tubulin tyrosine ligase like 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:9866222-9866442 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:9867034-9867534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:9867535-9868035 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:9868869-9869369 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:9876763-9877262

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Incidence and persistence of 8-oxo-7,8-dihydroguanine within a hairpin intermediate exacerbates a toxic oxidation cycle associated with trinucleotide repeat expansion. Jarem DA, et al. DNA Repair (Amst), 2011 Aug 15. PMID 21727036, Free PMC Article
  2. hOGG1 Ser326Cys polymorphism and renal cell carcinoma risk in a Chinese population. Zhao H, et al. DNA Cell Biol, 2011 May. PMID 21166493
  3. Tissue hOGG1 genotype predicts bladder cancer prognosis: a novel approach using a peptide nucleic acid clamping method. Ha YS, et al. Ann Surg Oncol, 2011 Jun. PMID 21184188
  4. Separation-of-function mutants unravel the dual-reaction mode of human 8-oxoguanine DNA glycosylase. Dalhus B, et al. Structure, 2011 Jan 12. PMID 21220122
  5. Association of the C-285T and A5954G polymorphisms in the DNA repair gene OGG1 with the susceptibility of rheumatoid arthritis. Chen SY, et al. Rheumatol Int, 2012 May. PMID 21253737

See all (655) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural basis for human OGG1 processing 8-oxodGuo within nucleosome core particles.
    Title: Structural basis for human OGG1 processing 8-oxodGuo within nucleosome core particles.
  2. 8-Oxoguanine DNA Glycosylase1 conceals oxidized guanine in nucleoprotein-associated RNA of respiratory syncytial virus.
    Title: 8-Oxoguanine DNA Glycosylase1 conceals oxidized guanine in nucleoprotein-associated RNA of respiratory syncytial virus.
  3. OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage.
    Title: OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage.
  4. Human 8-oxoguanine glycosylase OGG1 binds nucleosome at the dsDNA ends and the super-helical locations.
    Title: Human 8-oxoguanine glycosylase OGG1 binds nucleosome at the dsDNA ends and the super-helical locations.
  5. OGG1 prevents atherosclerosis-induced vascular endothelial cell injury through mediating DNA damage repair.
    Title: OGG1 prevents atherosclerosis-induced vascular endothelial cell injury through mediating DNA damage repair.
  6. SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner.
    Title: SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner.
  7. Association between polymorphisms of the DNA repair genes RAD51 and OGG1 and risk of cardiovascular disease.
    Title: Association between polymorphisms of the DNA repair genes RAD51 and OGG1 and risk of cardiovascular disease.
  8. Single-molecule analysis of purified proteins and nuclear extracts: Insights from 8-oxoguanine glycosylase 1.
    Title: Single-molecule analysis of purified proteins and nuclear extracts: Insights from 8-oxoguanine glycosylase 1.
  9. The 24-h profile of the DNA repair enzyme 8-oxoguanine glycosylase 1 (OGG1) is associated with age, TNF-alpha, and waist circumference in healthy adults.
    Title: The 24-h profile of the DNA repair enzyme 8-oxoguanine glycosylase 1 (OGG1) is associated with age, TNF-α, and waist circumference in healthy adults.
  10. Investigation of APE1 and OGG1 expression in chronic hemodialysis patients.
    Title: Investigation of APE1 and OGG1 expression in chronic hemodialysis patients.
Submit: New GeneRIF Correction See all GeneRIFs (500)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Nonpapillary renal cell carcinoma
MedGen: CN074294 OMIM: 144700 GeneReviews: Not available
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat appears to upregulate OGG1 expression by sequestrating AP-4 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables damaged DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables endonuclease activity TAS
Traceable Author Statement
more info
 PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidized purine DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidized purine nucleobase lesion DNA N-glycosylase activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in base-excision repair TAS
Traceable Author Statement
more info
 PubMed 
involved_in base-excision repair, AP site formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to cadmium ion IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in depurination TAS
Traceable Author Statement
more info
  
involved_in depyrimidination TAS
Traceable Author Statement
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of double-strand break repair via single-strand annealing IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within nucleotide-excision repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of gene expression via chromosomal CpG island demethylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
  
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
  
involved_in response to folic acid IEA
Inferred from Electronic Annotation
more info
  
involved_in response to light stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to radiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
  
located_in mitochondrion HTP PubMed 
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
N-glycosylase/DNA lyase
Names
8-hydroxyguanine DNA glycosylase
AP lyase
DNA-apurinic or apyrimidinic site lyase
OGG1 type 1f
NP_001341577.1
NP_001341578.1
NP_001341579.1
NP_001341580.1
NP_001341581.1
NP_002533.1
NP_058212.1
NP_058213.1
NP_058214.1
NP_058434.1
NP_058436.1
NP_058437.1
NP_058438.1
XP_016861982.1
XP_016861983.1
XP_016861984.1
XP_016861986.1
XP_047304156.1
XP_047304157.1
XP_047304158.1
XP_047304159.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012106.2 RefSeqGene

    Range
    5002..12457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001354648.2 → NP_001341577.1  N-glycosylase/DNA lyase isoform 1d

    Status: REVIEWED

    Source sequence(s)
    AC022382
    Conserved Domains (1) summary
    TIGR00588
    Location:11 → 189
    ogg; 8-oxoguanine DNA-glycosylase (ogg)

  2. NM_001354649.2 → NP_001341578.1  N-glycosylase/DNA lyase isoform 1e

    Status: REVIEWED

    Source sequence(s)
    AC022382
    Conserved Domains (1) summary
    TIGR00588
    Location:11 → 217
    ogg; 8-oxoguanine DNA-glycosylase (ogg)

  3. NM_001354650.2 → NP_001341579.1  N-glycosylase/DNA lyase isoform 2f

    Status: REVIEWED

    Source sequence(s)
    AC022382
    UniProtKB/TrEMBL
    A0A9L9PXU1
    Related
    ENSP00000516725.1, ENST00000707074.1
    Conserved Domains (1) summary
    TIGR00588
    Location:11 → 249
    ogg; 8-oxoguanine DNA-glycosylase (ogg)

  4. NM_001354651.2 → NP_001341580.1  N-glycosylase/DNA lyase isoform 2g

    Status: REVIEWED

    Source sequence(s)
    AC022382
    UniProtKB/TrEMBL
    E5KPS3
    Conserved Domains (1) summary
    TIGR00588
    Location:11 → 300
    ogg; 8-oxoguanine DNA-glycosylase (ogg)

  5. NM_001354652.2 → NP_001341581.1  N-glycosylase/DNA lyase isoform 2h

    Status: REVIEWED

    Source sequence(s)
    AC022382
    Conserved Domains (1) summary
    TIGR00588
    Location:11 → 249
    ogg; 8-oxoguanine DNA-glycosylase (ogg)

  6. NM_001434445.1 → NP_001421374.1  N-glycosylase/DNA lyase isoform 3a

    Status: REVIEWED

    Source sequence(s)
    AC022382

  7. NM_001434446.1 → NP_001421375.1  N-glycosylase/DNA lyase isoform 3b

    Status: REVIEWED

    Source sequence(s)
    AC022382

  8. NM_001434447.1 → NP_001421376.1  N-glycosylase/DNA lyase isoform 4a

    Status: REVIEWED

    Source sequence(s)
    AC022382

  9. NM_001434448.1 → NP_001421377.1  N-glycosylase/DNA lyase isoform 4b

    Status: REVIEWED

    Source sequence(s)
    AC022382

  10. NM_001434449.1 → NP_001421378.1  N-glycosylase/DNA lyase isoform 4c

    Status: REVIEWED

    Source sequence(s)
    AC022382

  11. NM_001434450.1 → NP_001421379.1  N-glycosylase/DNA lyase isoform 4d

    Status: REVIEWED

    Source sequence(s)
    AC022382

  12. NM_002542.6 → NP_002533.1  N-glycosylase/DNA lyase isoform 1a

    See identical proteins and their annotated locations for NP_002533.1

    Status: REVIEWED

    Description
    Transcript Variant: Transcript variant 1a represents the predominant form of this gene.
    Source sequence(s)
    BM847736, U88527, Y11838
    Consensus CDS
    CCDS2581.1
    UniProtKB/Swiss-Prot
    A8K1E3, O00390, O00670, O00705, O14876, O15527, O95488, P78554, Q9BW42, Q9UIK0, Q9UIK1, Q9UIK2, Q9UL34, Q9Y2C0, Q9Y2C1, Q9Y6C3, Q9Y6C4
    UniProtKB/TrEMBL
    E5KPN1, E5KPS3
    Related
    ENSP00000342851.7, ENST00000344629.12
    Conserved Domains (1) summary
    TIGR00588
    Location:11 → 328
    ogg; 8-oxoguanine DNA-glycosylase (ogg)

  13. NM_016819.4 → NP_058212.1  N-glycosylase/DNA lyase isoform 1b

    See identical proteins and their annotated locations for NP_058212.1

    Status: REVIEWED

    Description
    Transcript Variant: Transcript variant 1b contains a 244 bp insertion between exons 6 and 7, as compared to the predominant transcript variant 1a.
    Source sequence(s)
    AB019532, AC022382, BM847736, U88527, Y11838
    Consensus CDS
    CCDS43046.1
    UniProtKB/TrEMBL
    E5KPS3
    Related
    ENSP00000345520.5, ENST00000339511.9
    Conserved Domains (3) summary
    TIGR00588
    Location:11 → 317
    ogg; 8-oxoguanine DNA-glycosylase (ogg)
    cd00056
    Location:139 → 316
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    pfam07934
    Location:25 → 141
    OGG_N; 8-oxoguanine DNA glycosylase, N-terminal domain

  14. NM_016820.4 → NP_058213.1  N-glycosylase/DNA lyase isoform 1c

    See identical proteins and their annotated locations for NP_058213.1

    Status: REVIEWED

    Description
    Transcript Variant: Transcript variant 1c contains a 17 bp insertion before exon 7, as compared to the predominant transcript variant 1a.
    Source sequence(s)
    AB019532, BM847736, U88527, U96710, Y11838
    Consensus CDS
    CCDS2580.1
    UniProtKB/TrEMBL
    E5KPN0, E5KPS2
    Related
    ENSP00000305584.7, ENST00000302003.11
    Conserved Domains (3) summary
    TIGR00588
    Location:11 → 316
    ogg; 8-oxoguanine DNA-glycosylase (ogg)
    cd00056
    Location:139 → 316
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    pfam07934
    Location:25 → 141
    OGG_N; 8-oxoguanine DNA glycosylase, N-terminal domain

  15. NM_016821.3 → NP_058214.1  N-glycosylase/DNA lyase isoform 2a

    See identical proteins and their annotated locations for NP_058214.1

    Status: REVIEWED

    Description
    Transcript Variant: Transcript variant 2a contains an alternate exon 8 instead of exon 7, as compared to the predominant transcript variant 1a.
    Source sequence(s)
    AW614399, BM847736, U88620
    Consensus CDS
    CCDS2576.1
    UniProtKB/TrEMBL
    E5KPM5, E5KPS3
    Related
    ENSP00000306561.7, ENST00000302036.12
    Conserved Domains (3) summary
    TIGR00588
    Location:11 → 322
    ogg; 8-oxoguanine DNA-glycosylase (ogg)
    cd00056
    Location:139 → 319
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    pfam07934
    Location:25 → 141
    OGG_N; 8-oxoguanine DNA glycosylase, N-terminal domain

  16. NM_016826.3 → NP_058434.1  N-glycosylase/DNA lyase isoform 2b

    See identical proteins and their annotated locations for NP_058434.1

    Status: REVIEWED

    Description
    Transcript Variant: Transcript variant 2b contains an alternate exon 8 and skips exons 5 and 6, as compared to the predominant transcript variant 1a.
    Source sequence(s)
    AB019528, AW614399, BM847736, U88527
    Consensus CDS
    CCDS2577.1
    UniProtKB/TrEMBL
    E5KPM6
    Related
    ENSP00000344899.6, ENST00000352937.6
    Conserved Domains (2) summary
    cd00056
    Location:139 → 273
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    pfam07934
    Location:25 → 141
    OGG_N; 8-oxoguanine DNA glycosylase, N-terminal domain

  17. NM_016827.3 → NP_058436.1  N-glycosylase/DNA lyase isoform 2c

    See identical proteins and their annotated locations for NP_058436.1

    Status: REVIEWED

    Description
    Transcript Variant: Transcript variant 2c contains an alternate exon 8 and skips exons 4 to 6, as compared to the predominant transcript variant 1a.
    Source sequence(s)
    AB019529, AW614399, BM847736, U88527
    Consensus CDS
    CCDS2578.1
    UniProtKB/TrEMBL
    E5KPM8, H7C0A1
    Related
    ENSP00000373337.5, ENST00000383826.9
    Conserved Domains (2) summary
    pfam07934
    Location:25 → 141
    OGG_N; 8-oxoguanine DNA glycosylase, N-terminal domain
    cl23768
    Location:139 → 168
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases

  18. NM_016828.3 → NP_058437.1  N-glycosylase/DNA lyase isoform 2d

    See identical proteins and their annotated locations for NP_058437.1

    Status: REVIEWED

    Description
    Transcript Variant: Transcript variant 2d contains an alternate exon 8 and a 100 bp insertion, as compared to the predominant transcript variant 1a.
    Source sequence(s)
    AB019530, AW614399, BM847736, U88527
    Consensus CDS
    CCDS2579.1
    UniProtKB/TrEMBL
    E5KPM7, E5KPS3
    Related
    ENSP00000305527.8, ENST00000302008.12
    Conserved Domains (3) summary
    TIGR00588
    Location:11 → 316
    ogg; 8-oxoguanine DNA-glycosylase (ogg)
    cd00056
    Location:139 → 317
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    pfam07934
    Location:25 → 141
    OGG_N; 8-oxoguanine DNA glycosylase, N-terminal domain

  19. NM_016829.3 → NP_058438.1  N-glycosylase/DNA lyase isoform 2e

    See identical proteins and their annotated locations for NP_058438.1

    Status: REVIEWED

    Description
    Transcript Variant: Transcript variant 2e contains an alternate exon 8 and a 53 bp insertion between exons 6 and 8, as compared to the predominant transcript variant 1a.
    Source sequence(s)
    AB019531, AW614399, BM847736, U88527
    Consensus CDS
    CCDS46742.1
    UniProtKB/TrEMBL
    E5KPM9, E5KPS3
    Related
    ENSP00000403598.2, ENST00000449570.6
    Conserved Domains (1) summary
    TIGR00588
    Location:11 → 316
    ogg; 8-oxoguanine DNA-glycosylase (ogg)

RNA

  1. NR_148930.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022382

  2. NR_148931.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022382

  3. NR_148932.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022382

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    9749952..9783108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448200.1 → XP_047304156.1  N-glycosylase/DNA lyase isoform X4

  2. XM_017006497.3 → XP_016861986.1  N-glycosylase/DNA lyase isoform X5

  3. XM_047448201.1 → XP_047304157.1  N-glycosylase/DNA lyase isoform X6

  4. XM_047448202.1 → XP_047304158.1  N-glycosylase/DNA lyase isoform X6

  5. XM_017006494.3 → XP_016861983.1  N-glycosylase/DNA lyase isoform X2

  6. XM_017006495.3 → XP_016861984.1  N-glycosylase/DNA lyase isoform X3

  7. XM_017006493.3 → XP_016861982.1  N-glycosylase/DNA lyase isoform X1

    UniProtKB/TrEMBL
    E5KPS2
    Conserved Domains (2) summary
    cd00056
    Location:139 → 250
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    pfam07934
    Location:25 → 141
    OGG_N; 8-oxoguanine DNA glycosylase, N-terminal domain

  8. XM_047448203.1 → XP_047304159.1  N-glycosylase/DNA lyase isoform X7

    Related
    ENSP00000393726.1, ENST00000429146.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    9741907..9758605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15527.2 GenPept UniProtKB/Swiss-Prot:O15527

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