OGN osteoglycin [Homo sapiens (human)] - Gene

Summary

Official Symbol: OGNprovided by HGNC
Official Full Name: osteoglycinprovided by HGNC
Primary source: HGNC:HGNC:8126
See related: Ensembl:ENSG00000106809 MIM:602383; AllianceGenome:HGNC:8126
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: OG; OIF; SLRR3A
Summary: This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression: Broad expression in gall bladder (RPKM 88.2), endometrium (RPKM 64.5) and 14 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q22.31

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (92383268..92404699, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (104549769..104571196, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (95145550..95166981, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serum osteoglycin is stable during various glycemic challenges in healthy men.
Title: Serum osteoglycin is stable during various glycemic challenges in healthy men.
Osteoglycin (OGN) promotes tumorigenesis of pancreatic cancer cell via targeting ID4.
Title: Osteoglycin (OGN) promotes tumorigenesis of pancreatic cancer cell via targeting ID4.
Increased proteolytic cleavage of osteoglycin is associated with a stable plaque phenotype and lower risk of cardiovascular events.
Title: Increased proteolytic cleavage of osteoglycin is associated with a stable plaque phenotype and lower risk of cardiovascular events.
Chrysophanol inhibits the osteoglycin/mTOR and activats NF2 signaling pathways to reduce viability and proliferation of malignant meningioma cells.
Title: Chrysophanol inhibits the osteoglycin/mTOR and activats NF2 signaling pathways to reduce viability and proliferation of malignant meningioma cells.
Differential expression of Lumican, Mimecan, Annexin A5 and Serotransferrin in ectopic and matched eutopic endometrium in ovarian endometriosis: a case-control study.
Title: Differential expression of Lumican, Mimecan, Annexin A5 and Serotransferrin in ectopic and matched eutopic endometrium in ovarian endometriosis: a case-control study.
The proteoglycan mimecan is associated with carotid plaque vulnerability and increased risk of future cardiovascular death.
Title: The proteoglycan mimecan is associated with carotid plaque vulnerability and increased risk of future cardiovascular death.
Osteoglycin knockdown promotes vascular smooth muscle cell proliferation and migration in aortic dissection via the VEGF/VEGFR2 axis.
Title: Osteoglycin knockdown promotes vascular smooth muscle cell proliferation and migration in aortic dissection via the VEGF/VEGFR2 axis.
Overexpressed microRNA-140 inhibits pulmonary fibrosis in interstitial lung disease via the Wnt signaling pathway by downregulating osteoglycin.
Title: Overexpressed microRNA-140 inhibits pulmonary fibrosis in interstitial lung disease via the Wnt signaling pathway by downregulating osteoglycin.
Circular RNA hsa_circ_0076906 competes with OGN for miR-1305 biding site to alleviate the progression of osteoporosis.
Title: Circular RNA hsa_circ_0076906 competes with OGN for miR-1305 biding site to alleviate the progression of osteoporosis.
serum concentration not associated with carotid atherosclerosis plaque in essential hypertensive patients
Title: Association of SLRPs with carotid artery atherosclerosis in essential hypertensive patients.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH16376 (e-PCR)
- UniSTS:52815

OGN_8519 (e-PCR)
- UniSTS:467810

RH80964 (e-PCR)
- UniSTS:91747

RH36468 (e-PCR)
- UniSTS:72100

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent conferring compression resistance	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in articular cartilage development	IBA Inferred from Biological aspect of Ancestor more info
involved_in bone development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of smooth muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi lumen	TAS Traceable Author Statement more info
colocalizes_with collagen-containing extracellular matrix	HDA more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
located_in extracellular vesicle	HDA more info	PubMed
located_in lysosomal lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: mimecan

Names: corneal keratan sulfate proteoglycan; mimecan proteoglycan; osteoinductive factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014057.5 → NP_054776.1 mimecan isoform 2 precursor

See identical proteins and their annotated locations for NP_054776.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same isoform (2).

Source sequence(s)

AF086912, AF100758, AK295433, AL137848, BM679549

Consensus CDS

CCDS6695.1

UniProtKB/Swiss-Prot

P20774, Q6FIB0, Q9UF90, Q9UNK5

UniProtKB/TrEMBL

A8K0R3, Q7Z532

Related

ENSP00000364711.5, ENST00000375561.10

Conserved Domains (2) summary

sd00033
Location:123 → 144

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:143 → 225

LRR_8; Leucine rich repeat
NM_024416.4 → NP_077727.3 mimecan isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate translation start site compared to variant 1. The encoded isoform (1) has a longer N-terminus and lacks a predicted signal peptide compared to isoform 2.

Source sequence(s)

AF086912, AK295433, AL137848, BC095443, BG772245, BM679549

UniProtKB/TrEMBL

B4DI63, Q7Z532

Conserved Domains (3) summary

sd00033
Location:181 → 202

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:181 → 218

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:201 → 283

LRR_8; Leucine rich repeat
NM_033014.4 → NP_148935.1 mimecan isoform 2 precursor

See identical proteins and their annotated locations for NP_148935.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (2). Both variants 1 and 3 encode the same isoform (2).

Source sequence(s)

AL137848, BC095443, BG772245, BM679549, CB268982

Consensus CDS

CCDS6695.1

UniProtKB/Swiss-Prot

P20774, Q6FIB0, Q9UF90, Q9UNK5

UniProtKB/TrEMBL

A8K0R3, Q7Z532

Related

ENSP00000262551.4, ENST00000262551.8

Conserved Domains (2) summary

sd00033
Location:123 → 144

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:143 → 225

LRR_8; Leucine rich repeat