U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Impact impact RWD domain protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 497198, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Impactprovided by RGD
Official Full Name
impact RWD domain proteinprovided by RGD
Primary source
RGD:1591977
See related
EnsemblRapid:ENSRNOG00000045844 AllianceGenome:RGD:1591977
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin binding activity; protein sequestering activity; and ribosome binding activity. Predicted to be involved in several processes, including GCN2-mediated signaling; cellular response to amino acid starvation; and regulation of gene expression. Predicted to act upstream of or within negative regulation of protein phosphorylation. Predicted to be active in cytoplasm. Orthologous to human IMPACT (impact RWD domain protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 814.8), Thymus (RPKM 267.2) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Impact in Genome Data Viewer
Location:
18p13
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (4383546..4422280)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (4108872..4147571)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (4325872..4346734)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 1A Neighboring gene uncharacterized LOC102546723 Neighboring gene non-histone chromosomal protein HMG-17 pseudogene Neighboring gene uncharacterized LOC134482907 Neighboring gene histamine receptor H4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Comparative genomics approach toward critical determinants for the imprinting of an evolutionarily conserved gene Impact. Okamura K, et al. Biochem Biophys Res Commun, 2005 Apr 15. PMID 15752730
  2. IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth. Roffé M, et al. J Biol Chem, 2013 Apr 12. PMID 23447528, Free PMC Article
  3. Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2. Cambiaghi TD, et al. Biochem Biophys Res Commun, 2014 Jan 10. PMID 24333428
  4. Evidence that Yih1 resides in a complex with ribosomes. Waller T, et al. FEBS J, 2012 May. PMID 22404850
  5. Physiological Tau Interactome in Brain and Its Link to Tauopathies. Sinsky J, et al. J Proteome Res, 2020 Jun 5. PMID 32357304

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein sequestering activity ISO
Inferred from Sequence Orthology
more info
  
enables protein sequestering activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in GCN2-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GCN2-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in GCN2-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to amino acid starvation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron projection extension ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection extension ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cytoplasmic translational initiation in response to stress ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytoplasmic translational initiation in response to stress ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein IMPACT
Names
imprinted and ancient gene protein homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012235.1 → NP_001012235.1  protein IMPACT

    See identical proteins and their annotated locations for NP_001012235.1

    Status: PROVISIONAL

    Source sequence(s)
    AY574213
    UniProtKB/Swiss-Prot
    Q5GFD9
    UniProtKB/TrEMBL
    A0A8L2QV96, A6KLS9
    Related
    ENSRNOP00000102236.1, ENSRNOT00000121832.1
    Conserved Domains (2) summary
    smart00591
    Location:15 → 115
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    pfam01205
    Location:180 → 285
    UPF0029; Uncharacterized protein family UPF0029

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    4383546..4422280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277509.1 → XP_063133579.1  protein IMPACT isoform X1

    UniProtKB/Swiss-Prot
    Q5GFD9
    UniProtKB/TrEMBL
    A6KLS9

  2. XM_063277511.1 → XP_063133581.1  protein IMPACT isoform X1

    UniProtKB/Swiss-Prot
    Q5GFD9
    UniProtKB/TrEMBL
    A6KLS9

  3. XM_063277510.1 → XP_063133580.1  protein IMPACT isoform X1

    UniProtKB/Swiss-Prot
    Q5GFD9
    UniProtKB/TrEMBL
    A6KLS9

  4. XM_063277512.1 → XP_063133582.1  protein IMPACT isoform X1

    UniProtKB/Swiss-Prot
    Q5GFD9
    UniProtKB/TrEMBL
    A6KLS9

  5. XM_039097018.2 → XP_038952946.1  protein IMPACT isoform X1

    UniProtKB/Swiss-Prot
    Q5GFD9
    UniProtKB/TrEMBL
    A0A8L2QV96, A6KLS9
    Related
    ENSRNOP00000078372.1, ENSRNOT00000116602.2
    Conserved Domains (2) summary
    smart00591
    Location:15 → 115
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    pfam01205
    Location:180 → 285
    UPF0029; Uncharacterized protein family UPF0029
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5GFD9.1 GenPept UniProtKB/Swiss-Prot:Q5GFD9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools