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OPA1 OPA1 mitochondrial dynamin like GTPase [ Homo sapiens (human) ]

Gene ID: 4976, updated on 27-Nov-2024

Summary

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Official Symbol
OPA1provided by HGNC
Official Full Name
OPA1 mitochondrial dynamin like GTPaseprovided by HGNC
Primary source
HGNC:HGNC:8140
See related
Ensembl:ENSG00000198836 MIM:605290; AllianceGenome:HGNC:8140
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPG; NTG; MGM1; BERHS; largeG; MTDPS14
Summary
The protein encoded by this gene is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. The encoded protein localizes to the inner mitochondrial membrane and helps regulate mitochondrial stability and energy output. This protein also sequesters cytochrome c. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. [provided by RefSeq, Aug 2017]
Expression
Ubiquitous expression in brain (RPKM 20.5), heart (RPKM 17.2) and 25 other tissues See more
Orthologs
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Genomic context

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See OPA1 in Genome Data Viewer
Location:
3q29
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (193593208..193697811)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (196288807..196394453)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (193310997..193415600)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATPase 13A4 Neighboring gene ATP13A4 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:193310659-193311310 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:193311311-193311962 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 23 Neighboring gene OPA1 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:193364377-193365576 Neighboring gene uncharacterized LOC102724808 Neighboring gene MPRA-validated peak4976 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:193427999-193428934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:193428935-193429869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21005 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21007 Neighboring gene RNA, 7SL, cytoplasmic 447, pseudogene Neighboring gene uncharacterized LOC105374282 Neighboring gene VISTA enhancer hs1563

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Imaging of the macula indicates early completion of structural deficit in autosomal-dominant optic atrophy. Rönnbäck C, et al. Ophthalmology, 2013 Dec. PMID 24120325
  2. Association of OPA1 polymorphisms with NTG and HTG: a meta-analysis. Guo Y, et al. PLoS One, 2012. PMID 22879959, Free PMC Article
  3. OPA1 mutations induce mtDNA proliferation in leukocytes of patients with dominant optic atrophy. Sitarz KS, et al. Neurology, 2012 Oct 2. PMID 22993284, Free PMC Article
  4. OPA1 downregulation is involved in sorafenib-induced apoptosis in hepatocellular carcinoma. Zhao X, et al. Lab Invest, 2013 Jan. PMID 23108376, Free PMC Article
  5. Loss of OPA1 disturbs cellular calcium homeostasis and sensitizes for excitotoxicity. Kushnareva YE, et al. Cell Death Differ, 2013 Feb. PMID 23138851, Free PMC Article

See all (379) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characteristics of autosomal dominant WFS1-associated optic neuropathy and its comparability to OPA1-associated autosomal dominant optic atrophy.
    Title: Characteristics of autosomal dominant WFS1-associated optic neuropathy and its comparability to OPA1-associated autosomal dominant optic atrophy.
  2. Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy.
    Title: Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy.
  3. OPA1, a molecular regulator of dilated cardiomyopathy.
    Title: OPA1, a molecular regulator of dilated cardiomyopathy.
  4. OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response.
    Title: OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response.
  5. Melatonin Rescues Influenza A Virus-Induced Cellular Energy Exhaustion via OMA1-OPA1-S in Acute Exacerbation of COPD.
    Title: Melatonin Rescues Influenza A Virus-Induced Cellular Energy Exhaustion via OMA1-OPA1-S in Acute Exacerbation of COPD.
  6. OPA1 mutation affects autophagy and triggers senescence in autosomal dominant optic atrophy plus fibroblasts.
    Title: OPA1 mutation affects autophagy and triggers senescence in autosomal dominant optic atrophy plus fibroblasts.
  7. Human Platelet Derived Mitochondrial OPA-1 Isoforms and Interaction With TDP-43 in Neurodegenerative Diseases.
    Title: Human Platelet Derived Mitochondrial OPA-1 Isoforms and Interaction With TDP-43 in Neurodegenerative Diseases.
  8. p32/OPA1 axis-mediated mitochondrial dynamics contributes to cisplatin resistance in non-small cell lung cancer.
    Title: p32/OPA1 axis-mediated mitochondrial dynamics contributes to cisplatin resistance in non-small cell lung cancer.
  9. Human retinal organoids with an OPA1 mutation are defective in retinal ganglion cell differentiation and function.
    Title: Human retinal organoids with an OPA1 mutation are defective in retinal ganglion cell differentiation and function.
  10. Role of mitochondrial fusion proteins MFN2 and OPA1 on lung cellular senescence in chronic obstructive pulmonary disease.
    Title: Role of mitochondrial fusion proteins MFN2 and OPA1 on lung cellular senescence in chronic obstructive pulmonary disease.
Submit: New GeneRIF Correction See all GeneRIFs (244)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of optic atrophy 1 (OPA1, dynamin-like 120 kDa protein, mitochondrial) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12460, KIAA0567

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity TAS
Traceable Author Statement
more info
 PubMed 
enables GTPase-dependent fusogenic activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cardiolipin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables membrane bending activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables membrane scission GTPase motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in GTP metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in axonal transport of mitochondrion TAS
Traceable Author Statement
more info
 PubMed 
involved_in cellular senescence IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cristae formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cristae formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inner mitochondrial membrane organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular distribution of mitochondria IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane fusion IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane tubulation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial fission TAS
Traceable Author Statement
more info
 PubMed 
involved_in mitochondrial fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial fusion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial fusion TAS
Traceable Author Statement
more info
 PubMed 
involved_in mitochondrial genome maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial inner membrane fusion IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of release of cytochrome c from mitochondria IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neural tube closure IEA
Inferred from Electronic Annotation
more info
  
involved_in peroxisome fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T-helper 17 cell lineage commitment ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of interleukin-17 production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein complex oligomerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in visual perception IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in membrane HDA PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial crista IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
  
is_active_in mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial intermembrane space ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HTP PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
dynamin-like GTPase OPA1, mitochondrial
Names
dynamin-like 120 kDa protein, mitochondrial
dynamin-like guanosine triphosphatase
mitochondrial dynamin-like GTPase
optic atrophy 1 (autosomal dominant)
optic atrophy protein 1
NP_001341592.1
NP_001341593.1
NP_056375.2
NP_570844.1
NP_570845.1
NP_570846.1
NP_570847.2
NP_570848.1
NP_570849.2
NP_570850.2
XP_047304162.1
XP_047304163.1
XP_047304164.1
XP_047304165.1
XP_047304166.1
XP_047304167.1
XP_047304168.1
XP_047304169.1
XP_047304170.1
XP_047304172.1
XP_054202630.1
XP_054202631.1
XP_054202632.1
XP_054202633.1
XP_054202634.1
XP_054202635.1
XP_054202636.1
XP_054202637.1
XP_054202638.1
XP_054202639.1
XP_054202640.1
XP_054202641.1
XP_054202642.1
XP_054202643.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011605.1 RefSeqGene

    Range
    5001..109668
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_337

mRNA and Protein(s)

  1. NM_001354663.2 → NP_001341592.1  dynamin-like GTPase OPA1, mitochondrial isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC048351, AC106710
    UniProtKB/TrEMBL
    A0A2R8Y3X5
    Conserved Domains (1) summary
    cd08771
    Location:164 → 438
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

  2. NM_001354664.2 → NP_001341593.1  dynamin-like GTPase OPA1, mitochondrial isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC048351, AC106710
    UniProtKB/TrEMBL
    A0A2R8Y3X5
    Related
    ENSP00000493673.1, ENST00000643329.1
    Conserved Domains (1) summary
    cd08771
    Location:163 → 437
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

  3. NM_015560.3 → NP_056375.2  dynamin-like GTPase OPA1, mitochondrial isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_056375.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the original transcript identified. It contains 29 exons and encodes an isoform (1) of 960 aa.
    Source sequence(s)
    AC048351, AC106710
    Consensus CDS
    CCDS43186.1
    UniProtKB/Swiss-Prot
    D3DNW4, E5KLJ5, E5KLJ6, E5KLJ7, E5KLK1, E5KLK2, O60313
    UniProtKB/TrEMBL
    E5KLM2
    Related
    ENSP00000354429.3, ENST00000361828.7
    Conserved Domains (1) summary
    cd08771
    Location:287 → 561
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

  4. NM_130831.3 → NP_570844.1  dynamin-like GTPase OPA1, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_570844.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing exon 4, compared to transcript variant 1. It however, maintains the same reading frame and encodes an isoform (2) of 924 aa. This variant is based on an alternate splice pattern characterized by Delettre et al (2001, PMID: 11810270), but the complete 5' to 3' exon combination is inferred and not supported at the time of review by a single long cDNA.
    Source sequence(s)
    AC048351, AC106710, BQ774938
    Consensus CDS
    CCDS87183.1
    UniProtKB/TrEMBL
    E5KLM2
    Related
    ENSP00000494512.1, ENST00000646793.1
    Conserved Domains (1) summary
    cd08771
    Location:251 → 525
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

  5. NM_130832.3 → NP_570845.1  dynamin-like GTPase OPA1, mitochondrial isoform 3

    See identical proteins and their annotated locations for NP_570845.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is missing exon 4, but contains exon 4b, compared to transcript variant 1. It however, maintains the same reading frame and encodes an isoform (3) of 942 aa. This variant is based on an alternate splice pattern characterized by Delettre et al (2001, PMID: 11810270), but the complete 5' to 3' exon combination is inferred and not supported at the time of review by a single long cDNA.
    Source sequence(s)
    AC048351, AC106710, BQ774938
    UniProtKB/TrEMBL
    E5KLK0, E5KLM2
    Conserved Domains (1) summary
    cd08771
    Location:269 → 543
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

  6. NM_130833.3 → NP_570846.1  dynamin-like GTPase OPA1, mitochondrial isoform 4

    See identical proteins and their annotated locations for NP_570846.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) is missing exon 4, but contains exon 5b, compared to transcript variant 1. It however, maintains the same reading frame and encodes an isoform (4) of 961 aa. This variant is based on an alternate splice pattern characterized by Delettre et al (2001, PMID: 11810270), but the complete 5' to 3' exon combination is inferred and not supported at the time of review by a single long cDNA.
    Source sequence(s)
    AC048351, AC106710
    UniProtKB/TrEMBL
    E5KLM1
    Related
    ENSP00000354781.2, ENST00000361150.6
    Conserved Domains (1) summary
    cd08771
    Location:288 → 562
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

  7. NM_130834.3 → NP_570847.2  dynamin-like GTPase OPA1, mitochondrial isoform 5 preproprotein

    See identical proteins and their annotated locations for NP_570847.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an additional exon 4b, compared to transcript variant 1. It however, maintains the same reading frame and encodes an isoform (5) of 978 aa. This variant is based on an alternate splice pattern characterized by Delettre et al (2001, PMID: 11810270), but the complete 5' to 3' exon combination is inferred and not supported at the time of review by a single long cDNA.
    Source sequence(s)
    AC048351, AC106710, BQ774938
    UniProtKB/TrEMBL
    E5KLM0
    Related
    ENSP00000376232.2, ENST00000392437.6
    Conserved Domains (1) summary
    cd08771
    Location:305 → 579
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

  8. NM_130835.3 → NP_570848.1  dynamin-like GTPase OPA1, mitochondrial isoform 6

    See identical proteins and their annotated locations for NP_570848.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) is missing exon 4, but contains exons 4b and 5b, compared to transcript variant 1. It however, maintains the same reading frame and encodes an isoform (6) of 979 aa. This variant is based on an alternate splice pattern characterized by Delettre et al (2001, PMID: 11810270), but the complete 5' to 3' exon combination is inferred and not supported at the time of review by a single long cDNA.
    Source sequence(s)
    AC048351, AC106710
    UniProtKB/TrEMBL
    E5KLJ9, E5KLM1
    Related
    ENSP00000355311.2, ENST00000361715.6
    Conserved Domains (1) summary
    cd08771
    Location:306 → 580
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

  9. NM_130836.3 → NP_570849.2  dynamin-like GTPase OPA1, mitochondrial isoform 7

    See identical proteins and their annotated locations for NP_570849.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains an additional exon 5b, compared to transcript variant 1. It however, maintains the same reading frame and encodes an isoform (7) of 997 aa.
    Source sequence(s)
    AC048351, AC106710, BQ774938
    Consensus CDS
    CCDS33917.1
    UniProtKB/TrEMBL
    E5KLM1
    Related
    ENSP00000354681.3, ENST00000361908.8
    Conserved Domains (1) summary
    cd08771
    Location:324 → 598
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

  10. NM_130837.3 → NP_570850.2  dynamin-like GTPase OPA1, mitochondrial isoform 8

    See identical proteins and their annotated locations for NP_570850.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) contains 2 additional exons, 4b and 5b, compared to transcript variant 1. It however, maintains the same reading frame and encodes an isoform (8) of 1015 aa. This variant is based on an alternate splice pattern characterized by Delettre et al (2001, PMID: 11810270), but the complete 5' to 3' exon combination is inferred and not supported at the time of review by a single long cDNA.
    Source sequence(s)
    AC048351, AC106710
    UniProtKB/TrEMBL
    E5KLL9
    Related
    ENSP00000355324.2, ENST00000361510.8
    Conserved Domains (1) summary
    cd08771
    Location:342 → 616
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    193593208..193697811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448212.1 → XP_047304168.1  dynamin-like GTPase OPA1, mitochondrial isoform X7

  2. XM_047448206.1 → XP_047304162.1  dynamin-like GTPase OPA1, mitochondrial isoform X1

  3. XM_047448208.1 → XP_047304164.1  dynamin-like GTPase OPA1, mitochondrial isoform X3

  4. XM_047448207.1 → XP_047304163.1  dynamin-like GTPase OPA1, mitochondrial isoform X2

  5. XM_047448210.1 → XP_047304166.1  dynamin-like GTPase OPA1, mitochondrial isoform X5

    Related
    ENSP00000376231.3, ENST00000392436.7

  6. XM_047448209.1 → XP_047304165.1  dynamin-like GTPase OPA1, mitochondrial isoform X4

  7. XM_047448211.1 → XP_047304167.1  dynamin-like GTPase OPA1, mitochondrial isoform X6

  8. XM_047448213.1 → XP_047304169.1  dynamin-like GTPase OPA1, mitochondrial isoform X8

    Related
    ENSP00000495943.1, ENST00000644959.1

  9. XM_047448214.1 → XP_047304170.1  dynamin-like GTPase OPA1, mitochondrial isoform X9

  10. XM_047448216.1 → XP_047304172.1  dynamin-like GTPase OPA1, mitochondrial isoform X10

    Related
    ENSP00000495028.1, ENST00000646544.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    196288807..196394453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346660.1 → XP_054202635.1  dynamin-like GTPase OPA1, mitochondrial isoform X4

  2. XM_054346655.1 → XP_054202630.1  dynamin-like GTPase OPA1, mitochondrial isoform X1

  3. XM_054346666.1 → XP_054202641.1  dynamin-like GTPase OPA1, mitochondrial isoform X7

  4. XM_054346658.1 → XP_054202633.1  dynamin-like GTPase OPA1, mitochondrial isoform X3

  5. XM_054346664.1 → XP_054202639.1  dynamin-like GTPase OPA1, mitochondrial isoform X6

  6. XM_054346656.1 → XP_054202631.1  dynamin-like GTPase OPA1, mitochondrial isoform X2

  7. XM_054346661.1 → XP_054202636.1  dynamin-like GTPase OPA1, mitochondrial isoform X5

  8. XM_054346657.1 → XP_054202632.1  dynamin-like GTPase OPA1, mitochondrial isoform X11

  9. XM_054346662.1 → XP_054202637.1  dynamin-like GTPase OPA1, mitochondrial isoform X13

  10. XM_054346659.1 → XP_054202634.1  dynamin-like GTPase OPA1, mitochondrial isoform X12

  11. XM_054346663.1 → XP_054202638.1  dynamin-like GTPase OPA1, mitochondrial isoform X14

  12. XM_054346665.1 → XP_054202640.1  dynamin-like GTPase OPA1, mitochondrial isoform X15

  13. XM_054346667.1 → XP_054202642.1  dynamin-like GTPase OPA1, mitochondrial isoform X8

  14. XM_054346668.1 → XP_054202643.1  dynamin-like GTPase OPA1, mitochondrial isoform X10

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O60313.3 GenPept UniProtKB/Swiss-Prot:O60313

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