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Rmnd5b required for meiotic nuclear division 5 homolog B [ Rattus norvegicus (Norway rat) ]

Gene ID: 497900, updated on 4-Jan-2025

Summary

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Symbol
Rmnd5bprovided by RGD
Full Name
required for meiotic nuclear division 5 homolog Bprovided by RGD
Primary source
RGD:1559511
See related
EnsemblRapid:ENSRNOG00000047396 AllianceGenome:RGD:1559511
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be part of GID complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human RMND5B (required for meiotic nuclear division 5 homolog B). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 108.0), Testes (RPKM 101.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rmnd5b in Genome Data Viewer
Location:
10q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (36382212..36394801, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (35881250..35892322, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (34979902..34990985, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene NHP2 ribonucleoprotein Neighboring gene uncharacterized LOC102553843 Neighboring gene Nedd4 binding protein 3 Neighboring gene uncharacterized LOC120095096

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RMND5 from Xenopus laevis is an E3 ubiquitin-ligase and functions in early embryonic forebrain development. Pfirrmann T, et al. PLoS One, 2015. PMID 25793641, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC112682

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of GID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein transferase RMND5B
Names
protein RMD5 homolog B
NP_001017473.1
XP_006246267.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017473.1 → NP_001017473.1  E3 ubiquitin-protein transferase RMND5B

    See identical proteins and their annotated locations for NP_001017473.1

    Status: PROVISIONAL

    Source sequence(s)
    BC093386
    UniProtKB/TrEMBL
    Q566Q9
    Related
    ENSRNOP00000065529.1, ENSRNOT00000075555.4
    Conserved Domains (2) summary
    COG5109
    Location:60 → 393
    COG5109; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    pfam10607
    Location:155 → 299
    CLTH; CTLH/CRA C-terminal to LisH motif domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    36382212..36394801 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246205.4 → XP_006246267.1  E3 ubiquitin-protein transferase RMND5B isoform X1

    See identical proteins and their annotated locations for XP_006246267.1

    UniProtKB/TrEMBL
    Q566Q9
    Conserved Domains (2) summary
    COG5109
    Location:60 → 393
    COG5109; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    pfam10607
    Location:155 → 299
    CLTH; CTLH/CRA C-terminal to LisH motif domain
Nucleotide Protein Strain
Heading Accession and Version

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