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Myo19 myosin XIX [ Rattus norvegicus (Norway rat) ]

Gene ID: 497974, updated on 9-Dec-2024

Summary

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Official Symbol
Myo19provided by RGD
Official Full Name
myosin XIXprovided by RGD
Primary source
RGD:1559961
See related
EnsemblRapid:ENSRNOG00000002852 AllianceGenome:RGD:1559961
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1559961
Summary
Predicted to enable ATP hydrolysis activity; cytoskeletal protein binding activity; and plus-end directed microfilament motor activity. Predicted to be involved in several processes, including regulation of cytokinesis; regulation of mitochondrial fission; and vesicle transport along actin filament. Predicted to act upstream of or within mitochondrion migration along actin filament and mitocytosis. Predicted to be located in cytosol and mitochondrial outer membrane. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; cytoplasm; and vesicle. Orthologous to human MYO19 (myosin XIX). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Kidney (RPKM 101.8), Heart (RPKM 86.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Myo19 in Genome Data Viewer
Location:
10q26
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (70250500..70279867)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (69753082..69782450)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (72198475..72227892)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene gametogenetin binding protein 2 Neighboring gene zinc finger, HIT-type containing 3 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class W Neighboring gene U6 spliceosomal RNA Neighboring gene cytochrome c oxidase subunit 7B, pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Positively charged residues within the MYO19 MyMOMA domain are essential for proper localization of MYO19 to the mitochondrial outer membrane. Hawthorne JL, et al. Cytoskeleton (Hoboken), 2016 Jun. PMID 27126804, Free PMC Article
  2. Myo19 ensures symmetric partitioning of mitochondria and coupling of mitochondrial segregation to cell division. Rohn JL, et al. Curr Biol, 2014 Nov 3. PMID 25447992, Free PMC Article
  3. Biochemical and bioinformatic analysis of the myosin-XIX motor domain. Adikes RC, et al. Cytoskeleton (Hoboken), 2013 May. PMID 23568824, Free PMC Article
  4. Human Myo19 is a novel myosin that associates with mitochondria. Quintero OA, et al. Curr Biol, 2009 Dec 15. PMID 19932026, Free PMC Article
  5. Mouse myosin-19 is a plus-end-directed, high-duty ratio molecular motor. Lu Z, et al. J Biol Chem, 2014 Jun 27. PMID 24825904, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myosin light chain binding ISO
Inferred from Sequence Orthology
more info
  
enables plus-end directed microfilament motor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitochondrion migration along actin filament ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial fission ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
unconventional myosin-XIX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163736.1 → NP_001157208.1  unconventional myosin-XIX

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HHM6, D3Z8I9
    Related
    ENSRNOP00000003886.3, ENSRNOT00000003886.8
    Conserved Domains (3) summary
    smart00242
    Location:38 → 754
    MYSc; Myosin. Large ATPases
    cd14880
    Location:49 → 746
    MYSc_Myo19; class XIX myosin, motor domain
    pfam00612
    Location:784 → 804
    IQ; IQ calmodulin-binding motif

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    70250500..70279867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269649.1 → XP_063125719.1  unconventional myosin-XIX isoform X1

  2. XM_063269651.1 → XP_063125721.1  unconventional myosin-XIX isoform X2

  3. XM_039086621.2 → XP_038942549.1  unconventional myosin-XIX isoform X3

    Conserved Domains (1) summary
    cl22853
    Location:49 → 659
    Motor_domain; Myosin and Kinesin motor domain

RNA

  1. XR_005489919.1 RNA Sequence

  2. XR_010055226.1 RNA Sequence

  3. XR_010055227.1 RNA Sequence

  4. XR_005489917.1 RNA Sequence

  5. XR_005489918.1 RNA Sequence

  6. XR_005489921.1 RNA Sequence

  7. XR_005489922.1 RNA Sequence

  8. XR_005489923.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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