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Spn55B Serpin 55B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 49803, updated on 4-Jan-2025

Summary

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Official Symbol
Spn55Bprovided by FlyBase
Official Full Name
Serpin 55Bprovided by FlyBase
Primary source
FLYBASE:FBgn0028983
Locus tag
Dmel_CG10913
See related
AllianceGenome:FB:FBgn0028983
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10913; Dmel\CG10913; sp-6; sp6; Sp6; spn55B; Spn6
Summary
Enables serine-type endopeptidase inhibitor activity. Involved in negative regulation of proteolysis. Predicted to be active in extracellular space. Is expressed in several structures, including embryonic/larval garland cell; embryonic/larval gut; embryonic/larval salivary gland; garland cell primordium; and gut section. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal recessive nonsyndromic deafness 91; and peeling skin syndrome 5. Orthologous to several human genes including SERPINB1 (serpin family B member 1); SERPINB2 (serpin family B member 2); and SERPINB6 (serpin family B member 6). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Spn55B in Genome Data Viewer
Location:
55B7-55B7; 2-84 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18126347..18128210)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14013852..14015715)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene staufen Neighboring gene Dorsal interacting protein 3 Neighboring gene Heat shock factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel Drosophila serpin that inhibits serine proteases. Han J, et al. FEBS Lett, 2000 Feb 25. PMID 10692585
  2. The Spn4 gene of Drosophila encodes a potent furin-directed secretory pathway serpin. Richer MJ, et al. Proc Natl Acad Sci U S A, 2004 Jul 20. PMID 15247425, Free PMC Article
  3. Deep sequencing of the prothoracic gland transcriptome reveals new players in insect ecdysteroidogenesis. Nakaoka T, et al. PLoS One, 2017. PMID 28257485, Free PMC Article
  4. Serpin Facilitates Tumor-Suppressive Cell Competition by Blocking Toll-Mediated Yki Activation in Drosophila. Katsukawa M, et al. Curr Biol, 2018 Jun 4. PMID 29804808
  5. The Drosophila serpins: multiple functions in immunity and morphogenesis. Reichhart JM, et al. Methods Enzymol, 2011. PMID 21683256

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serpin 55B
Names
CG10913-PA
Spn55B-PA
serine protease inhibitor 6
serpin 6
serpin55B

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18126347..18128210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080214.4 → NP_524953.1  serpin 55B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524953.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JV69
    Related
    FBpp0085912
    Conserved Domains (1) summary
    cd00172
    Location:13 → 370
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JV69 Q7JV69

Gene LinkOut

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