Spn38F Serpin 38F [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Spn38Fprovided by FlyBase
Official Full Name: Serpin 38Fprovided by FlyBase
Primary source: FLYBASE:FBgn0028986
Locus tag: Dmel_CG9334
See related: AllianceGenome:FB:FBgn0028986
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9334; Dmel\CG9334; sp3; Sp3; Spn3
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Involved in defense response to Gram-negative bacterium. Located in extracellular space. Is expressed in several structures, including adult head; adult hemolymph; female reproductive system; oviduct; and sperm storage organ. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; Nagashima-type palmoplantar keratosis; autosomal recessive nonsyndromic deafness 91; familial encephalopathy with neuroserpin inclusion bodies; and thrombophilia (multiple). Orthologous to several human genes including SERPINB1 (serpin family B member 1); SERPINB12 (serpin family B member 12); and SERPINB13 (serpin family B member 13). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (20836621..20837985, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (20836621..20837985, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of proteolysis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in sexual reproduction	HEP more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISM Inferred from Sequence Model more info	PubMed