U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cht4 Chitinase 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 49815, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Cht4provided by FlyBase
Official Full Name
Chitinase 4provided by FlyBase
Primary source
FLYBASE:FBgn0022700
Locus tag
Dmel_CG3986
See related
AllianceGenome:FB:FBgn0022700
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE62779; CG3986; Cht; cht4; CHT4; DmCht4; DmCHT4; Dmel\CG3986
Summary
Enables chitin binding activity and chitinase activity. Involved in chitin catabolic process. Located in extracellular space. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to several human genes including CHIA (chitinase acidic). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Cht4 in Genome Data Viewer
Location:
57B16-57B16; 2-92 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21065379..21067087, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16952884..16954592, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L54 Neighboring gene Chitinase 8 Neighboring gene Chitinase 12 Neighboring gene antisense RNA:CR44703 Neighboring gene Chitinase 9 Neighboring gene antisense RNA:CR44704 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Chitinases are a multi-gene family in Aedes, Anopheles and Drosophila. de la Vega H, et al. Insect Mol Biol, 1998 Aug. PMID 9662472
  2. Characterization of recombinant chitinase-like proteins of Drosophila melanogaster and Tribolium castaneum. Zhu Q, et al. Insect Biochem Mol Biol, 2008 Apr. PMID 18342251
  3. Loss of p24 function in Drosophila melanogaster causes a stress response and increased levels of NF-kappaB-regulated gene products. Boltz KA, et al. BMC Genomics, 2008 May 8. PMID 18466616, Free PMC Article
  4. Computational identification of novel chitinase-like proteins in the Drosophila melanogaster genome. Zhu Q, et al. Bioinformatics, 2004 Jan 22. PMID 14734306
  5. The biology of insect chitinases and their roles at chitinous cuticles. Rabadiya D, et al. Insect Biochem Mol Biol, 2024 Feb. PMID 38184175

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chitin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chitin binding IEA
Inferred from Electronic Annotation
more info
  
enables chitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chitin catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chitin catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
chitinase 4
Names
CG3986-PA
Cht4-PA
NP_524962.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21065379..21067087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080223.3 → NP_524962.2  chitinase 4 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524962.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SYH0, Q9W2M6
    Related
    FBpp0071472
    Conserved Domains (3) summary
    cd02872
    Location:26 → 371
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00636
    Location:28 → 351
    Glyco_18; Glyco_18 domain
    pfam01607
    Location:421 → 462
    CBM_14; Chitin binding Peritrophin-A domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O17423 O17423
Q9W2M6 Q9W2M6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools