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Styxl2 serine/threonine/tyrosine interacting like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498267, updated on 9-Dec-2024

Summary

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Official Symbol
Styxl2provided by RGD
Official Full Name
serine/threonine/tyrosine interacting like 2provided by RGD
Primary source
RGD:1560598
See related
EnsemblRapid:ENSRNOG00000003722 AllianceGenome:RGD:1560598
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dusp27; RGD1560598
Summary
Predicted to enable MAP kinase phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in negative regulation of MAPK cascade. Predicted to be active in cytoplasm. Orthologous to human STYXL2 (serine/threonine/tyrosine interacting like 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Muscle (RPKM 212.9) and Heart (RPKM 128.2) See more
Orthologs
human mouse all
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Genomic context

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See Styxl2 in Genome Data Viewer
Location:
13q23
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (80882341..80911458, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (78349361..78378480, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (84302824..84332899, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene POU class 2 homeobox 1 Neighboring gene uncharacterized LOC134481526 Neighboring gene glycoprotein A33 Neighboring gene cold shock domain-containing protein E1-like Neighboring gene maelstrom spermatogenic transposon silencer

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables MAP kinase phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine/tyrosine-interacting-like protein 2
Names
dual specificity phosphatase 27 (putative)
dual specificity phosphatase 27, atypical
inactive dual specificity phosphatase 27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191929.2 → NP_001178858.1  serine/threonine/tyrosine-interacting-like protein 2

    See identical proteins and their annotated locations for NP_001178858.1

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    D3ZRM0
    Conserved Domains (1) summary
    cd00127
    Location:133 → 275
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

  2. NM_001429955.1 → NP_001416884.1  serine/threonine/tyrosine-interacting-like protein 2

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    D3ZRM0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    80882341..80911458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250187.5 → XP_006250249.1  serine/threonine/tyrosine-interacting-like protein 2 isoform X1

    Related
    ENSRNOP00000004965.3, ENSRNOT00000004965.7
    Conserved Domains (1) summary
    cd00127
    Location:133 → 275
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

  2. XM_006250188.5 → XP_006250250.1  serine/threonine/tyrosine-interacting-like protein 2 isoform X1

    Conserved Domains (1) summary
    cd00127
    Location:133 → 275
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
Nucleotide Protein Strain
Heading Accession and Version

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