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Nectin4 nectin cell adhesion molecule 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498281, updated on 4-Jan-2025

Summary

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Official Symbol
Nectin4provided by RGD
Official Full Name
nectin cell adhesion molecule 4provided by RGD
Primary source
RGD:1559826
See related
EnsemblRapid:ENSRNOG00000004029 AllianceGenome:RGD:1559826
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pvrl4; RGD1559826
Summary
Predicted to enable identical protein binding activity and receptor ligand activity. Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and negative regulation of natural killer cell mediated cytotoxicity. Predicted to be located in plasma membrane. Predicted to be active in adherens junction. Orthologous to human NECTIN4 (nectin cell adhesion molecule 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 30.7), Kidney (RPKM 12.7) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nectin4 in Genome Data Viewer
Location:
13q24
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (86335027..86354152)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (83802589..83821711)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (89755665..89774185)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene nitrilase 1 Neighboring gene prefoldin subunit 2 Neighboring gene kelch domain containing 9 Neighboring gene Rho GTPase activating protein 30 Neighboring gene upstream transcription factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nectin ectodomain structures reveal a canonical adhesive interface. Harrison OJ, et al. Nat Struct Mol Biol, 2012 Sep. PMID 22902367, Free PMC Article
  2. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
involved_in symbiont entry into host cell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nectin-4
Names
poliovirus receptor-related 4
poliovirus receptor-related protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109076.2 → NP_001102546.1  nectin-4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001102546.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8I5YBQ6, A6JFY9
    Related
    ENSRNOP00000077279.1, ENSRNOT00000101973.2
    Conserved Domains (3) summary
    cd00096
    Location:265 → 328
    Ig; Immunoglobulin domain
    cd05888
    Location:37 → 145
    IgV_1_Nectin-4_like; First immunoglobulin (Ig) domain of nectin-4, and similar domains
    cd07704
    Location:148 → 241
    IgC1_2_Nectin-3-4_like; Second immunoglobulin (Ig) domain of nectin-3 and nectin-4 (poliovirus receptor related protein 4), and similar domains; member of the C1-set of Ig superfamily (IgSF) domains

  2. NM_001429807.1 → NP_001416736.1  nectin-4 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8I5YBQ6, D3ZET1

  3. NM_001429808.1 → NP_001416737.1  nectin-4 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8I5YBQ6, A6JFZ0

  4. NM_001429809.1 → NP_001416738.1  nectin-4 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8I5YBQ6, D3ZET1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    86335027..86354152
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090983.2 → XP_038946911.1  nectin-4 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y5A1, A0A8I5YBQ6
    Related
    ENSRNOP00000076530.1, ENSRNOT00000110850.2
    Conserved Domains (3) summary
    cd00096
    Location:265 → 328
    Ig; Immunoglobulin domain
    cd05888
    Location:37 → 145
    IgV_1_Nectin-4_like; First immunoglobulin (Ig) domain of nectin-4, and similar domains
    cd07704
    Location:148 → 241
    IgC1_2_Nectin-3-4_like; Second immunoglobulin (Ig) domain of nectin-3 and nectin-4 (poliovirus receptor related protein 4), and similar domains; member of the C1-set of Ig superfamily (IgSF) domains

  2. XM_017598898.3 → XP_017454387.1  nectin-4 isoform X1

    Related
    ENSRNOP00000005550.4, ENSRNOT00000005550.8
    Conserved Domains (3) summary
    cd00096
    Location:265 → 328
    Ig; Immunoglobulin domain
    cd05888
    Location:37 → 145
    IgV_1_Nectin-4_like; First immunoglobulin (Ig) domain of nectin-4, and similar domains
    cd07704
    Location:148 → 241
    IgC1_2_Nectin-3-4_like; Second immunoglobulin (Ig) domain of nectin-3 and nectin-4 (poliovirus receptor related protein 4), and similar domains; member of the C1-set of Ig superfamily (IgSF) domains

  3. XM_039090982.2 → XP_038946910.1  nectin-4 isoform X1

    Conserved Domains (3) summary
    cd00096
    Location:265 → 328
    Ig; Immunoglobulin domain
    cd05888
    Location:37 → 145
    IgV_1_Nectin-4_like; First immunoglobulin (Ig) domain of nectin-4, and similar domains
    cd07704
    Location:148 → 241
    IgC1_2_Nectin-3-4_like; Second immunoglobulin (Ig) domain of nectin-3 and nectin-4 (poliovirus receptor related protein 4), and similar domains; member of the C1-set of Ig superfamily (IgSF) domains

  4. XM_006250256.5 → XP_006250318.1  nectin-4 isoform X3

    Conserved Domains (3) summary
    cd00096
    Location:265 → 328
    Ig; Immunoglobulin domain
    cd05888
    Location:37 → 145
    IgV_1_Nectin-4_like; First immunoglobulin (Ig) domain of nectin-4, and similar domains
    cd07704
    Location:148 → 241
    IgC1_2_Nectin-3-4_like; Second immunoglobulin (Ig) domain of nectin-3 and nectin-4 (poliovirus receptor related protein 4), and similar domains; member of the C1-set of Ig superfamily (IgSF) domains
Nucleotide Protein Strain
Heading Accession and Version

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