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Etaa1 ETAA1 activator of ATR kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 498420, updated on 4-Jan-2025

Summary

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Official Symbol
Etaa1provided by RGD
Official Full Name
ETAA1 activator of ATR kinaseprovided by RGD
Primary source
RGD:1560957
See related
EnsemblRapid:ENSRNOG00000006185 AllianceGenome:RGD:1560957
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Etaa1l1; RGD1560957
Summary
Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including positive regulation of protein serine/threonine kinase activity; regulation of cell cycle phase transition; and replication fork processing. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nuclear replication fork. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 115.6), Spleen (RPKM 98.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Etaa1 in Genome Data Viewer
Location:
14q22
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (96500899..96515617, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (92298461..92314044, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (97196079..97199067, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096676 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC120096677 Neighboring gene uncharacterized LOC120096678 Neighboring gene uncharacterized LOC134481793

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic G2/M transition checkpoint ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
  
involved_in replication fork processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in replication fork processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear replication fork IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear replication fork ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ewing's tumor-associated antigen 1
Names
Ewing tumor-associated antigen 1
Ewing tumor-associated antigen 1-like 1
ewing's tumor-associated antigen 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109094.2 → NP_001102564.1  ewing's tumor-associated antigen 1

    See identical proteins and their annotated locations for NP_001102564.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8I6AIP4, A6JQ01, D3ZQ67
    Related
    ENSRNOP00000008135.6, ENSRNOT00000008135.8
    Conserved Domains (1) summary
    pfam15350
    Location:76 → 859
    ETAA1; Ewing's tumour-associated antigen 1 homologue

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    96500899..96515617 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273496.1 → XP_063129566.1  ewing's tumor-associated antigen 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AIP4

  2. XM_063273495.1 → XP_063129565.1  ewing's tumor-associated antigen 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AIP4

  3. XM_039092323.2 → XP_038948251.1  ewing's tumor-associated antigen 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AIP4
    Conserved Domains (1) summary
    pfam15350
    Location:1 → 709
    ETAA1; Ewing's tumor-associated antigen 1 homolog

  4. XM_039092321.2 → XP_038948249.1  ewing's tumor-associated antigen 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AIP4
    Conserved Domains (1) summary
    pfam15350
    Location:1 → 748
    ETAA1; Ewing's tumor-associated antigen 1 homolog

  5. XM_039092324.2 → XP_038948252.1  ewing's tumor-associated antigen 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AIP4
    Conserved Domains (1) summary
    pfam15350
    Location:1 → 669
    ETAA1; Ewing's tumor-associated antigen 1 homolog
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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