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Ccnb1ip1 cyclin B1 interacting protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498492, updated on 4-Jan-2025

Summary

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Official Symbol
Ccnb1ip1provided by RGD
Official Full Name
cyclin B1 interacting protein 1provided by RGD
Primary source
RGD:1561930
See related
EnsemblRapid:ENSRNOG00000026056 AllianceGenome:RGD:1561930
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in reciprocal meiotic recombination. Predicted to act upstream of or within blastocyst formation; chiasma assembly; and spermatid development. Predicted to be located in synaptonemal complex. Orthologous to human CCNB1IP1 (cyclin B1 interacting protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 21.9), Thymus (RPKM 18.7) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ccnb1ip1 in Genome Data Viewer
Location:
15p14
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (26488462..26504167, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (24014905..24031357, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (27720220..27736528, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 11 subfamily H member 4 Neighboring gene tetratricopeptide repeat domain 5 Neighboring gene small nucleolar RNA SNORD126 Neighboring gene poly (ADP-ribose) polymerase 2 Neighboring gene ribonuclease P RNA component H1 Neighboring gene telomerase associated protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination. Qiao H, et al. Nat Genet, 2014 Feb. PMID 24390283, Free PMC Article
  2. Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over. Ward JO, et al. PLoS Genet, 2007 Aug. PMID 17784788, Free PMC Article
  3. Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites. Holloway JK, et al. J Cell Biol, 2014 Jun 9. PMID 24891606, Free PMC Article
  4. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Fragoza R, et al. Nat Commun, 2019 Sep 12. PMID 31515488, Free PMC Article
  5. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chiasma assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in chiasma assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reciprocal meiotic recombination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatid development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in synaptonemal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase CCNB1IP1
Names
cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
NP_001020312.1
XP_006251966.1
XP_038949511.1
XP_038949513.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025141.1 → NP_001020312.1  E3 ubiquitin-protein ligase CCNB1IP1

    See identical proteins and their annotated locations for NP_001020312.1

    Status: VALIDATED

    Source sequence(s)
    BC091423
    UniProtKB/TrEMBL
    F7ETK5, Q5BJM2
    Related
    ENSRNOP00000031347.4, ENSRNOT00000029488.6
    Conserved Domains (2) summary
    smart00935
    Location:100 → 175
    OmpH; Outer membrane protein (OmpH-like)
    pfam14634
    Location:10 → 52
    zf-RING_5; zinc-RING finger domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    26488462..26504167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093585.2 → XP_038949513.1  E3 ubiquitin-protein ligase CCNB1IP1 isoform X3

    Conserved Domains (1) summary
    smart00935
    Location:45 → 122
    OmpH; Outer membrane protein (OmpH-like)

  2. XM_039093583.2 → XP_038949511.1  E3 ubiquitin-protein ligase CCNB1IP1 isoform X1

    UniProtKB/TrEMBL
    F7ETK5
    Related
    ENSRNOP00000112139.1, ENSRNOT00000128504.1
    Conserved Domains (2) summary
    smart00935
    Location:132 → 207
    OmpH; Outer membrane protein (OmpH-like)
    pfam14634
    Location:42 → 84
    zf-RING_5; zinc-RING finger domain

  3. XM_006251904.3 → XP_006251966.1  E3 ubiquitin-protein ligase CCNB1IP1 isoform X2

    See identical proteins and their annotated locations for XP_006251966.1

    UniProtKB/TrEMBL
    F7ETK5, Q5BJM2
    Conserved Domains (2) summary
    smart00935
    Location:100 → 175
    OmpH; Outer membrane protein (OmpH-like)
    pfam14634
    Location:10 → 52
    zf-RING_5; zinc-RING finger domain
Nucleotide Protein Strain
Heading Accession and Version

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