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Commd6 COMM domain containing 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498559, updated on 9-Dec-2024

Summary

Official Symbol
Commd6provided by RGD
Official Full Name
COMM domain containing 6provided by RGD
Primary source
RGD:1560745
See related
EnsemblRapid:ENSRNOG00000038012 AllianceGenome:RGD:1560745
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560745
Summary
Predicted to enable NF-kappaB binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within negative regulation of NF-kappaB transcription factor activity. Orthologous to human COMMD6 (COMM domain containing 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Kidney (RPKM 61.7), Thymus (RPKM 61.0) and 9 other tissues See more
Orthologs
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Genomic context

See Commd6 in Genome Data Viewer
Location:
15q21
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (84882069..84889124, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (78467333..78474382, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (86136096..86142672, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 4 Neighboring gene ubiquinol-cytochrome c reductase, complex III subunit X, pseudogene 1 Neighboring gene ubiquitin C-terminal hydrolase L3 Neighboring gene HCLS1 associated protein X-1, pseudogene 3 Neighboring gene uncharacterized LOC134482002 Neighboring gene LIM domain 7

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General protein information

Preferred Names
COMM domain-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109105.1NP_001102575.1  COMM domain-containing protein 6

    See identical proteins and their annotated locations for NP_001102575.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473951
    UniProtKB/TrEMBL
    A6HU73, D4A8E7
    Related
    ENSRNOP00000054640.2, ENSRNOT00000057830.4
    Conserved Domains (1) summary
    cl06336
    Location:29106
    Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    84882069..84889124 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274567.1XP_063130637.1  COMM domain-containing protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AV93, A6HU72
    Related
    ENSRNOP00000097644.1, ENSRNOT00000120224.2
  2. XM_063274568.1XP_063130638.1  COMM domain-containing protein 6 isoform X2