Prxl2c peroxiredoxin like 2C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prxl2cprovided by RGD
Official Full Name: peroxiredoxin like 2Cprovided by RGD
Primary source: RGD:1589650
See related: EnsemblRapid:ENSRNOG00000018886 AllianceGenome:RGD:1589650
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Aaed1
Summary: Predicted to be involved in positive regulation of ERK1 and ERK2 cascade and positive regulation of glycolytic process. Orthologous to human PRXL2C (peroxiredoxin like 2C). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 95.0), Heart (RPKM 89.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (817932..849965)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (812199..839536)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (1798224..1830011, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU029075 (e-PCR)
- UniSTS:111722

BE102255 (e-PCR)
- UniSTS:244110

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycolytic process	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peroxiredoxin-like 2C

Names: AhpC/TSA antioxidant enzyme domain containing 1; thioredoxin-like protein AAED1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399210.1 → NP_001386139.1 peroxiredoxin-like 2C isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A8I6G5D2, A6KQE1

Related

ENSRNOP00000079468.1, ENSRNOT00000109028.2

Conserved Domains (1) summary

cd02970
Location:34 → 195

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
NM_001399211.1 → NP_001386140.1 peroxiredoxin-like 2C isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A8I6A506

Related

ENSRNOP00000086014.1, ENSRNOT00000104207.2

Conserved Domains (1) summary

cd02970
Location:34 → 168

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

817932..849965

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039095988.2 → XP_038951916.1 peroxiredoxin-like 2C isoform X2

Conserved Domains (1) summary

cd02970
Location:34 → 134

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
XM_063276679.1 → XP_063132749.1 peroxiredoxin-like 2C isoform X3

UniProtKB/TrEMBL

A6KQD9, D3ZAK1
XM_039095987.2 → XP_038951915.1 peroxiredoxin-like 2C isoform X1

Related

ENSRNOP00000062637.2, ENSRNOT00000066230.3

Conserved Domains (1) summary

cd02970
Location:34 → 192

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

RNA

XR_010058909.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001109114.1: Suppressed sequence

Description

NM_001109114.1: This RefSeq was removed because currently there is insufficient support for the transcript.