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Fbxl8 F-box and leucine-rich repeat protein 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498941, updated on 4-Jan-2025

Summary

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Official Symbol
Fbxl8provided by RGD
Official Full Name
F-box and leucine-rich repeat protein 8provided by RGD
Primary source
RGD:1566420
See related
EnsemblRapid:ENSRNOG00000015242 AllianceGenome:RGD:1566420
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1566420
Summary
Orthologous to human FBXL8 (F-box and leucine rich repeat protein 8). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 24.1), Thymus (RPKM 20.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fbxl8 in Genome Data Viewer
Location:
19q11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50048221..50057191)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33142705..33147266)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37216696..37225701)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene phagophore assembly factor 1 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 Neighboring gene TNFRSF1A-associated via death domain Neighboring gene heat shock transcription factor 4 Neighboring gene microtubule associated tyrosine carboxypeptidase 1 Neighboring gene nucleolar protein 3 Neighboring gene exocyst complex component 3-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

General protein information

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Preferred Names
F-box/LRR-repeat protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396452.1 → NP_001383381.1  F-box/LRR-repeat protein 8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A6IYM6
    Related
    ENSRNOP00000020441.5, ENSRNOT00000020440.7
    Conserved Domains (2) summary
    sd00034
    Location:103 → 136
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:5 → 34
    F-box-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    50048221..50057191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063278190.1 → XP_063134260.1  F-box/LRR-repeat protein 8 isoform X1

    UniProtKB/TrEMBL
    A6IYM6

  2. XM_006255521.5 → XP_006255583.1  F-box/LRR-repeat protein 8 isoform X2

    UniProtKB/TrEMBL
    D3ZYT9
    Conserved Domains (1) summary
    sd00034
    Location:72 → 105
    LRR_AMN1; leucine-rich repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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