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Tmem258 transmembrane protein 258 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499317, updated on 4-Jan-2025

Summary

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Official Symbol
Tmem258provided by RGD
Official Full Name
transmembrane protein 258provided by RGD
Primary source
RGD:1560328
See related
EnsemblRapid:ENSRNOG00000072429 AllianceGenome:RGD:1560328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560328
Summary
Predicted to enable oligosaccharyltransferase complex binding activity. Predicted to act upstream of or within several processes, including epithelial cell apoptotic process; protein N-linked glycosylation; and response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of oligosaccharyltransferase complex. Orthologous to human TMEM258 (transmembrane protein 258). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 233.4), Thymus (RPKM 200.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmem258 in Genome Data Viewer
Location:
1q43
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (216274607..216278505)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (206849723..206853623)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (226256142..226260006)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene S-formylglutathione hydrolase-like Neighboring gene fatty acid desaturase 1 Neighboring gene flap structure-specific endonuclease 1 Neighboring gene myelin regulatory factor Neighboring gene diacylglycerol lipase, alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Gene essentiality and synthetic lethality in haploid human cells. Blomen VA, et al. Science, 2015 Nov 27. PMID 26472760
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables oligosaccharyltransferase complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within epithelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inflammatory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
part_of oligosaccharyltransferase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane protein 258

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401078.1 → NP_001388007.1  transmembrane protein 258

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6I013
    Related
    ENSRNOP00000100863.1, ENSRNOT00000129597.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    216274607..216278505
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094970.2 → XP_038950898.1  transmembrane protein 258 isoform X1

    Conserved Domains (1) summary
    pfam05251
    Location:10 → 82
    Ost5; Oligosaccharyltransferase subunit 5
Nucleotide Protein Strain
Heading Accession and Version

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