Mcm9 minichromosome maintenance 9 homologous recombination repair factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Mcm9provided by RGD
Full Name: minichromosome maintenance 9 homologous recombination repair factorprovided by RGD
Primary source: RGD:1560557
See related: EnsemblRapid:ENSRNOG00000003281 AllianceGenome:RGD:1560557
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mcmdc1; RGD1560557
Summary: Predicted to enable several functions, including DNA helicase activity; mismatch repair complex binding activity; and single-stranded DNA binding activity. Predicted to contribute to single-stranded DNA helicase activity. Predicted to be involved in several processes, including DNA duplex unwinding; DNA repair; and protein localization to chromatin. Predicted to be located in chromosome. Predicted to be part of MCM8-MCM9 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in ovarian dysgenesis 4. Orthologous to human MCM9 (minichromosome maintenance 9 homologous recombination repair factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 65.6), Spleen (RPKM 48.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (33369325..33472243, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (32818219..32929577, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (34818093..34930157, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identified a novel MCM family gene, MCM9, by using bioinformatics; mouse MCM9 mRNA was upregulated by transcription factor E2E1 and serum stimulation in NIH3T3 cells.
Title: Identification of a novel cell-cycle-induced MCM family protein MCM9.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables DNA helicase activity	ISO Inferred from Sequence Orthology more info
enables MutLbeta complex binding	IEA Inferred from Electronic Annotation more info
enables MutLbeta complex binding	ISO Inferred from Sequence Orthology more info
enables MutSalpha complex binding	IEA Inferred from Electronic Annotation more info
enables MutSalpha complex binding	ISO Inferred from Sequence Orthology more info
enables MutSbeta complex binding	IEA Inferred from Electronic Annotation more info
enables MutSbeta complex binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables forked DNA-dependent helicase activity	IEA Inferred from Electronic Annotation more info
enables four-way junction helicase activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables single-stranded 3'-5' DNA helicase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
involved_in DNA duplex unwinding	ISO Inferred from Sequence Orthology more info
NOT involved_in DNA replication	ISO Inferred from Sequence Orthology more info
NOT involved_in DNA replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in female gamete generation	ISO Inferred from Sequence Orthology more info
involved_in female gamete generation	ISS Inferred from Sequence or Structural Similarity more info
involved_in gamete generation	ISO Inferred from Sequence Orthology more info
involved_in gamete generation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication	IEA Inferred from Electronic Annotation more info
involved_in mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication	ISO Inferred from Sequence Orthology more info
involved_in protein localization to chromatin	IEA Inferred from Electronic Annotation more info
involved_in protein localization to chromatin	ISO Inferred from Sequence Orthology more info
involved_in recombinational interstrand cross-link repair	IEA Inferred from Electronic Annotation more info
involved_in recombinational interstrand cross-link repair	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of MCM8-MCM9 complex	IEA Inferred from Electronic Annotation more info
part_of MCM8-MCM9 complex	ISO Inferred from Sequence Orthology more info
part_of MCM8-MCM9 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA helicase MCM9

Names: Mini-chromosome maintenance deficient domain-containing protein 1; minichromosome maintenance complex component 9; minichromosome maintenance deficient domain containing 1

NP_001403310.1

EC 3.6.4.12

XP_008771231.1

EC 3.6.4.12

XP_063135540.1

EC 3.6.4.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001416381.1 → NP_001403310.1 DNA helicase MCM9

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

F1M5F3

UniProtKB/TrEMBL

K3W4U8

Related

ENSRNOP00000004499.6, ENSRNOT00000004499.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

33369325..33472243 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063279470.1 → XP_063135540.1 DNA helicase MCM9 isoform X1

UniProtKB/TrEMBL

A6K494
XM_008773009.4 → XP_008771231.1 DNA helicase MCM9 isoform X2

See identical proteins and their annotated locations for XP_008771231.1

UniProtKB/TrEMBL

A6K498

Conserved Domains (3) summary

COG1241
Location:10 → 383

Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]

pfam14551
Location:13 → 128

MCM_N; MCM N-terminal domain

cl21455
Location:347 → 375

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases