U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GCS2alpha Glucosidase 2 alpha subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 49953, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
GCS2alphaprovided by FlyBase
Official Full Name
Glucosidase 2 alpha subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0027588
Locus tag
Dmel_CG14476
See related
AllianceGenome:FB:FBgn0027588
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH04962; CG14476; clot#312; Dmel\CG14476
Summary
Predicted to enable glucan 1,3-alpha-glucosidase activity. Predicted to be involved in N-glycan processing. Located in endomembrane system and extracellular region. Is expressed in several structures, including adult head; adult heart; anterior endoderm; gut section; and mesoderm. Human ortholog(s) of this gene implicated in polycystic kidney disease; polycystic kidney disease 3; and polycystic liver disease. Orthologous to several human genes including GANAB (glucosidase II alpha subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See GCS2alpha in Genome Data Viewer
Location:
20A4-20A4; 1-66 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21600502..21605264, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21471529..21476291, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46472 Neighboring gene long non-coding RNA:CR44711 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Two isoforms of trimming glucosidase II exist in mammalian tissues and cell lines but not in yeast and insect cells. Ziak M, et al. Biochem Biophys Res Commun, 2001 Jan 12. PMID 11162524
  2. Characterization of the flamenco region of the Drosophila melanogaster genome. Robert V, et al. Genetics, 2001 Jun. PMID 11404334, Free PMC Article
  3. [Analysis of the structure and expression of the cluster of Drosophila melanogaster genes DIP1, CG32500, CG32819, and CG14476 in the flamenco gene region]. Potapova MV, et al. Genetika, 2009 Oct. PMID 19947543
  4. Discovery of insect and human dengue virus host factors. Sessions OM, et al. Nature, 2009 Apr 23. PMID 19396146, Free PMC Article
  5. Mutations in four glycosyl hydrolases reveal a highly coordinated pathway for rhodopsin biosynthesis and N-glycan trimming in Drosophila melanogaster. Rosenbaum EE, et al. PLoS Genet, 2014 May. PMID 24785692, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Analysis of the structure and expression of the cluster of Drosophila melanogaster genes DIP1, CG32500, CG32819, and CG14476 in the flamenco gene region
    Title: [Analysis of the structure and expression of the cluster of Drosophila melanogaster genes DIP1, CG32500, CG32819, and CG14476 in the flamenco gene region].
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

mobile_element

  • Loc: c21604380-21604032 mobile_element_type = transposon:INE-1{}2000

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables alpha-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables glucan 1,3-alpha-glucosidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
located_in extracellular region HDA PubMed 
part_of glucosidase II complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
glucosidase 2 alpha subunit
Names
CG14476-PA
CG14476-PB
CG14476-PC
CG14476-PD
CG14476-PE
GCS2alpha-PA
GCS2alpha-PB
GCS2alpha-PC
GCS2alpha-PD
GCS2alpha-PE
alpha-glucosidase
glucosidase II
NP_652145.1
NP_728434.1
NP_728435.1
NP_728436.1
NP_728437.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    21600502..21605264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167758.2 → NP_728435.1  glucosidase 2 alpha subunit, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728435.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KMM4
    Related
    FBpp0070058
    Conserved Domains (3) summary
    cd06603
    Location:362 → 833
    GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
    cd14752
    Location:224 → 362
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam01055
    Location:343 → 792
    Glyco_hydro_31; Glycosyl hydrolases family 31

  2. NM_143888.5 → NP_652145.1  glucosidase 2 alpha subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652145.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KMM4
    Related
    FBpp0070057
    Conserved Domains (3) summary
    cd06603
    Location:362 → 833
    GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
    cd14752
    Location:224 → 362
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam01055
    Location:343 → 792
    Glyco_hydro_31; Glycosyl hydrolases family 31

  3. NM_167757.3 → NP_728434.1  glucosidase 2 alpha subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728434.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KMM4
    Related
    FBpp0070059
    Conserved Domains (3) summary
    cd06603
    Location:362 → 833
    GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
    cd14752
    Location:224 → 362
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam01055
    Location:343 → 792
    Glyco_hydro_31; Glycosyl hydrolases family 31

  4. NM_167760.1 → NP_728437.1  glucosidase 2 alpha subunit, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728437.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KMM4
    Related
    FBpp0070060, FBtr0070061
    Conserved Domains (3) summary
    cd06603
    Location:362 → 833
    GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
    cd14752
    Location:224 → 362
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam01055
    Location:343 → 792
    Glyco_hydro_31; Glycosyl hydrolases family 31

  5. NM_167759.2 → NP_728436.1  glucosidase 2 alpha subunit, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728436.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KMM4
    Related
    FBpp0070061
    Conserved Domains (3) summary
    cd06603
    Location:362 → 833
    GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
    cd14752
    Location:224 → 362
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam01055
    Location:343 → 792
    Glyco_hydro_31; Glycosyl hydrolases family 31
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KMM4 Q7KMM4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools