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Med22 mediator complex subunit 22 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499762, updated on 4-Jan-2025

Summary

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Symbol
Med22provided by RGD
Full Name
mediator complex subunit 22provided by RGD
Primary source
RGD:1564893
See related
EnsemblRapid:ENSRNOG00000005059 AllianceGenome:RGD:1564893
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Surf5; RGD1564893
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Orthologous to human MED22 (mediator complex subunit 22). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 72.7), Adrenal (RPKM 71.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Med22 in Genome Data Viewer
Location:
3p13
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (30631829..30636911, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (10233754..10238836, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (5453678..5458760, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene endosulfine alpha, pseudogene 1 Neighboring gene surfeit 6 Neighboring gene small nucleolar RNA SNORD36 Neighboring gene small nucleolar RNA, C/D box 24 Neighboring gene ribosomal protein L7A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. Tomomori-Sato C, et al. J Biol Chem, 2004 Feb 13. PMID 14638676
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of core mediator complex ISO
Inferred from Sequence Orthology
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 22
Names
mediator of RNA polymerase II transcription subunit 22-like
surfeit 5
surfeit locus protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077679.1 → NP_001071147.1  mediator of RNA polymerase II transcription subunit 22

    See identical proteins and their annotated locations for NP_001071147.1

    Status: PROVISIONAL

    Source sequence(s)
    BC127519
    UniProtKB/Swiss-Prot
    A0JPN6
    UniProtKB/TrEMBL
    A6JTI3
    Related
    ENSRNOP00000006720.3, ENSRNOT00000006720.6
    Conserved Domains (1) summary
    pfam06179
    Location:20 → 124
    Med22; Surfeit locus protein 5 subunit 22 of Mediator complex

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    30631829..30636911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0JPN6.1 GenPept UniProtKB/Swiss-Prot:A0JPN6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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