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Rad51 RAD51 recombinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 499870, updated on 9-Dec-2024

Summary

Official Symbol
Rad51provided by RGD
Official Full Name
RAD51 recombinaseprovided by RGD
Primary source
RGD:1563603
See related
EnsemblRapid:ENSRNOG00000037302 AllianceGenome:RGD:1563603
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563603
Summary
Predicted to enable several functions, including ATP binding activity; DNA binding activity; and catalytic activity, acting on DNA. Involved in several processes, including cellular response to cisplatin; cellular response to gamma radiation; and response to X-ray. Predicted to be located in several cellular components, including chromosome; male germ cell nucleus; and nuclear lumen. Predicted to be part of nuclear ubiquitin ligase complex. Predicted to be active in condensed nuclear chromosome; presynaptic intermediate filament cytoskeleton; and site of double-strand break. Used to study cardiomyopathy and hypertension. Biomarker of pancreatic cancer. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group R; breast cancer; congenital mirror movement disorder; and ovarian cancer. Orthologous to human RAD51 (RAD51 recombinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Thymus (RPKM 112.8), Spleen (RPKM 60.0) and 9 other tissues See more
Orthologs
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Genomic context

See Rad51 in Genome Data Viewer
Location:
3q35
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (126554210..126578888)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (106099753..106125038)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (110918240..110942920)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene transfer RNA serine (anticodon GCU) 4 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene kinetochore scaffold 1 Neighboring gene regulator of microtubule dynamics 3 Neighboring gene glycine cleavage system H protein, mitochondrial pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA polymerase binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA strand exchange activity ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables single-stranded DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA recombinase assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA unwinding involved in DNA replication ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to alkaloid ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to camptothecin ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cisplatin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to gamma radiation IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular response to hydroxyurea ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chromosome organization involved in meiotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in double-strand break repair involved in meiotic recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in double-strand break repair via homologous recombination IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in interstrand cross-link repair ISO
Inferred from Sequence Orthology
more info
 
involved_in meiosis I IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within meiotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic recombination-dependent replication fork processing IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA ligation ISO
Inferred from Sequence Orthology
more info
 
involved_in reciprocal meiotic recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within replication fork processing ISO
Inferred from Sequence Orthology
more info
 
involved_in replication fork processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within replication-born double-strand break repair via sister chromatid exchange ISO
Inferred from Sequence Orthology
more info
 
involved_in response to X-ray IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to glucoside IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to toxic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in telomere maintenance via recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in telomere maintenance via telomere lengthening ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within telomere organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
located_in condensed chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in lateral element ISO
Inferred from Sequence Orthology
more info
 
located_in male germ cell nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
 
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA repair protein RAD51 homolog 1
Names
RAD51 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109204.1NP_001102674.1  DNA repair protein RAD51 homolog 1

    See identical proteins and their annotated locations for NP_001102674.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473949
    UniProtKB/TrEMBL
    A0A8I6GJP5, A6HPE0, B5DF04, F7EX62
    Related
    ENSRNOP00000053270.4, ENSRNOT00000056432.4
    Conserved Domains (1) summary
    TIGR02239
    Location:25339
    recomb_RAD51; DNA repair protein RAD51

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    126554210..126578888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284362.1XP_063140432.1  DNA repair protein RAD51 homolog 1 isoform X2

  2. XM_063284363.1XP_063140433.1  DNA repair protein RAD51 homolog 1 isoform X3

  3. XM_006234784.5XP_006234846.1  DNA repair protein RAD51 homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006234846.1

    UniProtKB/TrEMBL
    A0A8I6GJP5, A6HPE0, B5DF04, F7EX62
    Conserved Domains (1) summary
    TIGR02239
    Location:25339
    recomb_RAD51; DNA repair protein RAD51