U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ap5s1 adaptor related protein complex 5 subunit sigma 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499893, updated on 27-Nov-2024

Summary

Official Symbol
Ap5s1provided by RGD
Official Full Name
adaptor related protein complex 5 subunit sigma 1provided by RGD
Primary source
RGD:1561852
See related
EnsemblRapid:ENSRNOG00000021249 AllianceGenome:RGD:1561852
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561852
Summary
Predicted to be involved in double-strand break repair via homologous recombination and endosomal transport. Predicted to be located in nucleoplasm. Predicted to be part of AP-type membrane coat adaptor complex. Predicted to be active in cytosol; late endosome; and lysosome. Orthologous to human AP5S1 (adaptor related protein complex 5 subunit sigma 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 55.4), Kidney (RPKM 51.3) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ap5s1 in Genome Data Viewer
Location:
3q36
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (138882634..138885940)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (118429618..118432929)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (123754035..123757349)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486156 Neighboring gene cell division cycle 25B Neighboring gene mitochondrial antiviral signaling protein Neighboring gene uncharacterized LOC134486155 Neighboring gene pantothenate kinase 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endosomal transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of AP-type membrane coat adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of AP-type membrane coat adaptor complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
AP-5 complex subunit sigma-1
Names
adaptor-related protein complex 5, sigma 1 subunit

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398912.1NP_001385841.1  AP-5 complex subunit sigma-1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A0G2K3F6
    Related
    ENSRNOP00000099228.1, ENSRNOT00000164731.1
    Conserved Domains (1) summary
    pfam15001
    Location:1193
    AP-5_subunit_s1; AP-5 complex subunit sigma-1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    138882634..138885940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105699.2XP_038961627.1  AP-5 complex subunit sigma-1 isoform X1

    Conserved Domains (1) summary
    pfam15001
    Location:170
    AP-5_subunit_s1; AP-5 complex subunit sigma-1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001134618.1: Suppressed sequence

    Description
    NM_001134618.1: This RefSeq was removed because currently there is insufficient support for the transcript.