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Bpifb1 BPI fold containing family B, member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499926, updated on 9-Dec-2024

Summary

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Official Symbol
Bpifb1provided by RGD
Official Full Name
BPI fold containing family B, member 1provided by RGD
Primary source
RGD:1563047
See related
EnsemblRapid:ENSRNOG00000015468 AllianceGenome:RGD:1563047
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lplunc1; RGD1563047
Summary
Predicted to enable lipid binding activity. Predicted to be involved in innate immune response in mucosa and negative regulation of toll-like receptor 4 signaling pathway. Predicted to be located in extracellular region. Orthologous to human BPIFB1 (BPI fold containing family B member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward (RPKM 77.7) See more
Orthologs
human mouse all
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Genomic context

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See Bpifb1 in Genome Data Viewer
Location:
3q41
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (163133151..163166420)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (142672995..142706258)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (149668099..149702399)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486304 Neighboring gene BPI fold containing family A, member 5 Neighboring gene BPI fold containing family B, member 5 Neighboring gene CDK5 regulatory subunit associated protein 1 Neighboring gene mortality factor 4 like 2, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. LPLUNC1 modulates innate immune responses to Vibrio cholerae. Shin OS, et al. J Infect Dis, 2011 Nov. PMID 21900486, Free PMC Article
  2. Human LPLUNC1 is a secreted product of goblet cells and minor glands of the respiratory and upper aerodigestive tracts. Bingle CD, et al. Histochem Cell Biol, 2010 May. PMID 20237794, Free PMC Article
  3. Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. Bingle CD, et al. Biochem Soc Trans, 2011 Aug. PMID 21787333, Free PMC Article
  4. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC156708

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in innate immune response in mucosa IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response in mucosa IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response in mucosa ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of toll-like receptor 4 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of toll-like receptor 4 signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
BPI fold-containing family B member 1
Names
fold containing family B, member 1
long palate, lung and nasal epithelium carcinoma-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077680.1 → NP_001071148.2  BPI fold-containing family B member 1 precursor

    Status: VALIDATED

    Source sequence(s)
    BC127515
    UniProtKB/Swiss-Prot
    A0JPN3
    UniProtKB/TrEMBL
    A0A140TAH2
    Related
    ENSRNOP00000052209.4, ENSRNOT00000055342.6
    Conserved Domains (2) summary
    cd00025
    Location:25 → 260
    BPI1; BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) N-terminal domain; binds to and neutralizes lipopolysaccharides from the outer ...
    cd00026
    Location:277 → 473
    BPI2; BPI/LBP/CETP C-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) C-terminal domain; binds to and neutralizes lipopolysaccharides from the outer ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    163133151..163166420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235355.4 → XP_006235417.1  BPI fold-containing family B member 1 isoform X1

    UniProtKB/Swiss-Prot
    A0JPN3
    UniProtKB/TrEMBL
    A0A8I5ZV17
    Related
    ENSRNOP00000082300.1, ENSRNOT00000118757.2
    Conserved Domains (2) summary
    cd00025
    Location:61 → 296
    BPI1; BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) N-terminal domain; binds to and neutralizes lipopolysaccharides from the outer ...
    cd00026
    Location:313 → 509
    BPI2; BPI/LBP/CETP C-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) C-terminal domain; binds to and neutralizes lipopolysaccharides from the outer ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0JPN3.1 GenPept UniProtKB/Swiss-Prot:A0JPN3

Gene LinkOut

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