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Cep41 centrosomal protein 41 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500069, updated on 4-Jan-2025

Summary

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Official Symbol
Cep41provided by RGD
Official Full Name
centrosomal protein 41provided by RGD
Primary source
RGD:1562034
See related
EnsemblRapid:ENSRNOG00000010950 AllianceGenome:RGD:1562034
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tsga14
Summary
Predicted to be involved in cilium assembly and protein polyglutamylation. Predicted to be located in centriole; centrosome; and cilium. Predicted to be active in ciliary basal body. Human ortholog(s) of this gene implicated in Joubert syndrome 15. Orthologous to human CEP41 (centrosomal protein 41). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 44.0), Thymus (RPKM 35.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cep41 in Genome Data Viewer
Location:
4q22
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (60238602..60279670, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (59271218..59312343, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (57966783..58006931, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene carboxypeptidase A5 Neighboring gene carboxypeptidase A1 Neighboring gene mesoderm specific transcript Neighboring gene COPI coat complex subunit gamma 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium. Lee JE, et al. Nat Genet, 2012 Jan 15. PMID 22246503, Free PMC Article
  2. Proteomic analysis of mammalian primary cilia. Ishikawa H, et al. Curr Biol, 2012 Mar 6. PMID 22326026, Free PMC Article
  3. Proteomic characterization of the human centrosome by protein correlation profiling. Andersen JS, et al. Nature, 2003 Dec 4. PMID 14654843
  4. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
  5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC112886

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein polyglutamylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary basal body IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
centrosomal protein of 41 kDa
Names
centrosomal protein 41kDa
testis specific gene A14
testis specific, 14
testis-specific gene A14 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025770.2 → NP_001020941.1  centrosomal protein of 41 kDa isoform 1

    See identical proteins and their annotated locations for NP_001020941.1

    Status: VALIDATED

    Source sequence(s)
    BC098832
    UniProtKB/Swiss-Prot
    F1LXL2, Q4KM37
    Related
    ENSRNOP00000014621.4, ENSRNOT00000014621.8
    Conserved Domains (1) summary
    cd00158
    Location:136 → 221
    RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...

  2. NM_001415927.1 → NP_001402856.1  centrosomal protein of 41 kDa isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A096MJP4, A0A8I5ZWA8, A6IEH4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    60238602..60279670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108120.2 → XP_038964048.1  centrosomal protein of 41 kDa isoform X1

    Conserved Domains (1) summary
    pfam00581
    Location:135 → 220
    Rhodanese; Rhodanese-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4KM37.1 GenPept UniProtKB/Swiss-Prot:Q4KM37

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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