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Wdr54 WD repeat domain 54 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500226, updated on 4-Jan-2025

Summary

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Symbol
Wdr54provided by RGD
Full Name
WD repeat domain 54provided by RGD
Primary source
RGD:1561494
See related
EnsemblRapid:ENSRNOG00000009324 AllianceGenome:RGD:1561494
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561494
Summary
Predicted to enable protein homodimerization activity. Involved in fusion of sperm to egg plasma membrane involved in single fertilization. Located in cytoplasm and plasma membrane. Orthologous to human WDR54 (WD repeat domain 54). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 76.4), Testes (RPKM 50.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wdr54 in Genome Data Viewer
Location:
4q34
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (117212677..117236456, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (115654968..115677979, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (114847722..114871989, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350719 Neighboring gene INO80 complex subunit B Neighboring gene rhotekin Neighboring gene similar to human chromosome 2 open reading frame 81 Neighboring gene dynactin subunit 1 Neighboring gene solute carrier family 4 member 5 Neighboring gene uncharacterized LOC134486596 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Participation of WD repeat-containing protein 54 (WDR54) in rat sperm-oocyte fusion through interaction with both IZUMO1 and JUNO. Lai X, et al. Theriogenology, 2024 Jan 15. PMID 37951137
  2. Transglutaminase-mediated cross-linking of WDR54 regulates EGF receptor-signaling. Maeda A, et al. Biochim Biophys Acta Mol Cell Res, 2019 Feb. PMID 30458214
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Participation of WD repeat-containing protein 54 (WDR54) in rat sperm-oocyte fusion through interaction with both IZUMO1 and JUNO.
    Title: Participation of WD repeat-containing protein 54 (WDR54) in rat sperm-oocyte fusion through interaction with both IZUMO1 and JUNO.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in fusion of sperm to egg plasma membrane involved in single fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in single fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
WD repeat-containing protein 54

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109245.1 → NP_001102715.1  WD repeat-containing protein 54

    See identical proteins and their annotated locations for NP_001102715.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473957
    UniProtKB/TrEMBL
    A6IAL0, D3ZX63
    Related
    ENSRNOP00000013128.3, ENSRNOT00000013128.7
    Conserved Domains (2) summary
    COG2319
    Location:131 → 324
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:72 → 119
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    117212677..117236456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236781.5 → XP_006236843.1  WD repeat-containing protein 54 isoform X1

    See identical proteins and their annotated locations for XP_006236843.1

    UniProtKB/TrEMBL
    A6IAL0, D3ZX63
    Conserved Domains (2) summary
    COG2319
    Location:131 → 324
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:72 → 119
    7WD40; WD40 repeat [structural motif]

  2. XM_006236780.5 → XP_006236842.1  WD repeat-containing protein 54 isoform X1

    See identical proteins and their annotated locations for XP_006236842.1

    UniProtKB/TrEMBL
    A6IAL0, D3ZX63
    Conserved Domains (2) summary
    COG2319
    Location:131 → 324
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:72 → 119
    7WD40; WD40 repeat [structural motif]

  3. XM_039108151.2 → XP_038964079.1  WD repeat-containing protein 54 isoform X1

    UniProtKB/TrEMBL
    A6IAL0, D3ZX63
    Conserved Domains (2) summary
    COG2319
    Location:131 → 324
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:72 → 119
    7WD40; WD40 repeat [structural motif]

  4. XM_006236778.4 → XP_006236840.1  WD repeat-containing protein 54 isoform X1

    See identical proteins and their annotated locations for XP_006236840.1

    UniProtKB/TrEMBL
    A6IAL0, D3ZX63
    Conserved Domains (2) summary
    COG2319
    Location:131 → 324
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:72 → 119
    7WD40; WD40 repeat [structural motif]

  5. XM_063286524.1 → XP_063142594.1  WD repeat-containing protein 54 isoform X1

    UniProtKB/TrEMBL
    A6IAL0, D3ZX63
Nucleotide Protein Strain
Heading Accession and Version

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