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Ankrd53 ankyrin repeat domain 53 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500230, updated on 4-Jan-2025

Summary

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Official Symbol
Ankrd53provided by RGD
Official Full Name
ankyrin repeat domain 53provided by RGD
Primary source
RGD:1561200
See related
EnsemblRapid:ENSRNOG00000021402 AllianceGenome:RGD:1561200
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561200
Summary
Predicted to be involved in mitotic metaphase chromosome alignment; regulation of microtubule cytoskeleton organization; and regulation of mitotic cytokinesis. Predicted to be located in spindle. Predicted to be active in spindle pole. Orthologous to human ANKRD53 (ankyrin repeat domain 53). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information
Annotation category: partial on reference assembly
Expression
Biased expression in Testes (RPKM 71.7), Heart (RPKM 61.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ankrd53 in Genome Data Viewer
Location:
4q34
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (117804702..117810650)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (116245561..116253018)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (115439325..115447995)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ventral anterior homeobox 2 Neighboring gene uncharacterized LOC108350721 Neighboring gene ATPase H+ transporting V1 subunit B1 Neighboring gene uncharacterized LOC134486595 Neighboring gene testis expressed 261 Neighboring gene 60S ribosomal protein L27 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ANKRD53 interacts with DDA3 and regulates chromosome integrity during mitosis. Kim S, et al. Biochem Biophys Res Commun, 2016 Feb 12. PMID 26820536
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in mitotic metaphase chromosome alignment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of microtubule polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in spindle ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ankyrin repeat domain 53; ankyrin repeat domain-containing protein 53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431826.1 → NP_001418755.1  ankyrin repeat domain 53

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6IAP4

  2. NM_001431827.1 → NP_001418756.1  ankyrin repeat domain 53

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6IAP4

  3. NM_001431828.1 → NP_001418757.1  ankyrin repeat domain 53

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6IAP4

  4. NM_001431829.1 → NP_001418758.1  ankyrin repeat domain 53

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6IAP4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    117804702..117810650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_056985480.2 → XP_056841460.2  ankyrin repeat domain-containing protein 53

    UniProtKB/TrEMBL
    F1M9S7
    Related
    ENSRNOP00000033393.4, ENSRNOT00000033234.7
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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