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Arhgap25 Rho GTPase activating protein 25 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500246, updated on 27-Nov-2024

Summary

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Official Symbol
Arhgap25provided by RGD
Official Full Name
Rho GTPase activating protein 25provided by RGD
Primary source
RGD:1562105
See related
EnsemblRapid:ENSRNOG00000009347 AllianceGenome:RGD:1562105
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562105
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in actin filament organization; negative regulation of small GTPase mediated signal transduction; and phagocytosis, engulfment. Predicted to be active in phagocytic cup. Orthologous to human ARHGAP25 (Rho GTPase activating protein 25). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 159.7), Thymus (RPKM 86.5) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arhgap25 in Genome Data Viewer
Location:
4q34
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (121454151..121532293, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (119896844..119974982, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (119249682..119327822, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene gastrokine 3 Neighboring gene bone morphogenetic protein 10 Neighboring gene prokineticin receptor 1 Neighboring gene uncharacterized LOC120102330 Neighboring gene aprataxin and PNKP like factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins. Schlam D, et al. Nat Commun, 2015 Oct 14. PMID 26465210, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in phagocytosis, engulfment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phagocytosis, engulfment ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in phagocytic cup IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagocytic cup ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109247.1 → NP_001102717.1  rho GTPase-activating protein 25

    See identical proteins and their annotated locations for NP_001102717.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473957
    UniProtKB/TrEMBL
    A0A8I6A5M6, A6IB08, D3ZGL1
    Related
    ENSRNOP00000012645.5, ENSRNOT00000012645.7
    Conserved Domains (3) summary
    cd04390
    Location:156 → 354
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13263
    Location:45 → 157
    PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
    pfam00169
    Location:47 → 149
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    121454151..121532293 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108163.2 → XP_038964091.1  rho GTPase-activating protein 25 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A5M6
    Conserved Domains (3) summary
    COG1196
    Location:518 → 619
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd04390
    Location:130 → 328
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    cd13263
    Location:19 → 131
    PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain

  2. XM_063286534.1 → XP_063142604.1  rho GTPase-activating protein 25 isoform X3

  3. XM_006236839.5 → XP_006236901.1  rho GTPase-activating protein 25 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A5M6
    Conserved Domains (4) summary
    cd04390
    Location:74 → 272
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam00169
    Location:6 → 67
    PH; PH domain
    pfam07989
    Location:490 → 561
    Cnn_1N; Centrosomin N-terminal motif 1
    cl17171
    Location:4 → 75
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version

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