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Phf24 PHD finger protein 24 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500446, updated on 9-Dec-2024

Summary

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Official Symbol
Phf24provided by RGD
Official Full Name
PHD finger protein 24provided by RGD
Primary source
RGD:1559864
See related
EnsemblRapid:ENSRNOG00000000129 AllianceGenome:RGD:1559864
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1559864
Summary
Predicted to enable metal ion binding activity. Predicted to act upstream of or within several processes, including detection of mechanical stimulus involved in sensory perception of pain; gamma-aminobutyric acid signaling pathway; and regulation of GABAergic synaptic transmission. Predicted to be active in glutamatergic synapse and synaptic vesicle membrane. Orthologous to human PHF24 (PHD finger protein 24). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Brain (RPKM 147.5) and Heart (RPKM 26.7) See more
Orthologs
human mouse all
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Genomic context

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See Phf24 in Genome Data Viewer
Location:
5q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (61939261..61966879)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (57143428..57171054)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (58359744..58387446)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene SPATA31 subfamily F member 1 Neighboring gene SPATA31 subfamily F member 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member B5 Neighboring gene SPATA31 subfamily G member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PHF24 is expressed in the inhibitory interneurons in rats. Numakura Y, et al. Exp Anim, 2021 Feb 6. PMID 33115988, Free PMC Article
  2. GINIP, a Gαi-interacting protein, functions as a key modulator of peripheral GABAB receptor-mediated analgesia. Gaillard S, et al. Neuron, 2014 Oct 1. PMID 25242222, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PHF24 is expressed in the inhibitory interneurons in rats.
    Title: PHF24 is expressed in the inhibitory interneurons in rats.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
PHD finger protein 24
Names
Gai-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398835.1 → NP_001385764.1  PHD finger protein 24

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A292G0W2, A0A8I6GMB9
    Conserved Domains (1) summary
    pfam16744
    Location:127 → 198
    Zf_RING; KIAA1045 RING finger

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    61939261..61966879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238122.5 → XP_006238184.1  PHD finger protein 24 isoform X1

    See identical proteins and their annotated locations for XP_006238184.1

    UniProtKB/TrEMBL
    A0A292G0W2, A0A8I6GMB9
    Conserved Domains (1) summary
    pfam16744
    Location:127 → 198
    Zf_RING; KIAA1045 RING finger

  2. XM_063288220.1 → XP_063144290.1  PHD finger protein 24 isoform X1

    UniProtKB/TrEMBL
    A0A292G0W2, A0A8I6GMB9

  3. XM_063288223.1 → XP_063144293.1  PHD finger protein 24 isoform X3

    UniProtKB/TrEMBL
    A0A292G0W2, D3ZB78

  4. XM_006238123.5 → XP_006238185.1  PHD finger protein 24 isoform X1

    See identical proteins and their annotated locations for XP_006238185.1

    UniProtKB/TrEMBL
    A0A292G0W2, A0A8I6GMB9
    Conserved Domains (1) summary
    pfam16744
    Location:127 → 198
    Zf_RING; KIAA1045 RING finger

  5. XM_017593720.3 → XP_017449209.1  PHD finger protein 24 isoform X3

    UniProtKB/TrEMBL
    A0A292G0W2, D3ZB78
    Conserved Domains (1) summary
    pfam16744
    Location:90 → 161
    Zf_RING; KIAA1045 RING finger

  6. XM_063288222.1 → XP_063144292.1  PHD finger protein 24 isoform X3

    UniProtKB/TrEMBL
    A0A292G0W2, D3ZB78
    Related
    ENSRNOP00000000141.3, ENSRNOT00000000141.7

  7. XM_039110972.2 → XP_038966900.1  PHD finger protein 24 isoform X1

    UniProtKB/TrEMBL
    A0A292G0W2, A0A8I6GMB9
    Related
    ENSRNOP00000096981.1, ENSRNOT00000120097.2
    Conserved Domains (1) summary
    pfam16744
    Location:127 → 198
    Zf_RING; KIAA1045 RING finger

  8. XM_039110974.2 → XP_038966902.1  PHD finger protein 24 isoform X1

    UniProtKB/TrEMBL
    A0A292G0W2, A0A8I6GMB9
    Conserved Domains (1) summary
    pfam16744
    Location:127 → 198
    Zf_RING; KIAA1045 RING finger

  9. XM_039110975.2 → XP_038966903.1  PHD finger protein 24 isoform X3

    UniProtKB/TrEMBL
    A0A292G0W2, D3ZB78
    Conserved Domains (1) summary
    pfam16744
    Location:90 → 161
    Zf_RING; KIAA1045 RING finger

  10. XM_017593718.3 → XP_017449207.1  PHD finger protein 24 isoform X2

    UniProtKB/TrEMBL
    A0A292G0W2

  11. XM_006238121.5 → XP_006238183.1  PHD finger protein 24 isoform X1

    See identical proteins and their annotated locations for XP_006238183.1

    UniProtKB/TrEMBL
    A0A292G0W2, A0A8I6GMB9
    Conserved Domains (1) summary
    pfam16744
    Location:127 → 198
    Zf_RING; KIAA1045 RING finger

  12. XM_017593719.3 → XP_017449208.1  PHD finger protein 24 isoform X3

    UniProtKB/TrEMBL
    A0A292G0W2, D3ZB78
    Conserved Domains (1) summary
    pfam16744
    Location:90 → 161
    Zf_RING; KIAA1045 RING finger

  13. XM_063288224.1 → XP_063144294.1  PHD finger protein 24 isoform X4

    UniProtKB/TrEMBL
    A6IIZ3
Nucleotide Protein Strain
Heading Accession and Version

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