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Tnfrsf9 TNF receptor superfamily member 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500590, updated on 9-Dec-2024

Summary

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Official Symbol
Tnfrsf9provided by RGD
Official Full Name
TNF receptor superfamily member 9provided by RGD
Primary source
RGD:1598208
See related
EnsemblRapid:ENSRNOG00000036942 AllianceGenome:RGD:1598208
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
4-1BB
Summary
Predicted to enable signaling receptor activity. Predicted to be involved in regulation of cell population proliferation. Predicted to act upstream of or within regulation of immature T cell proliferation in thymus. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TNFRSF9 (TNF receptor superfamily member 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Liver (RPKM 24.7), Thymus (RPKM 21.5) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tnfrsf9 in Genome Data Viewer
Location:
5q36
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (166664494..166690834)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (161381662..161408003)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (168009245..168035813)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ERBB receptor feedback inhibitor 1 Neighboring gene uncharacterized LOC102556316 Neighboring gene Parkinsonism associated deglycase Neighboring gene uncharacterized LOC134479048 Neighboring gene U1 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Gene silencing of 4-1BB by RNA interference inhibits acute rejection in rats with liver transplantation. Shi Y, et al. Biomed Res Int, 2013. PMID 23484089, Free PMC Article
  2. Expression of CD137 in the cerebral artery after experimental subarachnoid hemorrhage in rats: a pilot study. Zhang J, et al. Brain Res, 2011 Apr 22. PMID 21352817
  3. Attenuation of experimental autoimmune myocarditis by blocking T cell activation through 4-1BB pathway. Haga T, et al. J Mol Cell Cardiol, 2009 May. PMID 19233196
  4. Molecular cloning and protein characterization of swine 4-1BB. Zhao X, et al. Vet Immunol Immunopathol, 2013 May 15. PMID 23453329
  5. Characterisation of soluble murine CD137 and its association with systemic lupus. Shao Z, et al. Mol Immunol, 2008 Sep. PMID 18640726

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. gene silencing of 4-1BB by RNA interference inhibits the acute rejection in rats with liver transplantation.
    Title: Gene silencing of 4-1BB by RNA interference inhibits acute rejection in rats with liver transplantation.
  2. Upregulation of CD137 in the cerebral arterial wall may be important in the development of cerebral vasospasm following subarachnoid hemorrhage.
    Title: Expression of CD137 in the cerebral artery after experimental subarachnoid hemorrhage in rats: a pilot study.
  3. Blockade of T cell activation through the 4-1BB/4-1BBL pathway regulates development of experimental autoimmune myocarditis.
    Title: Attenuation of experimental autoimmune myocarditis by blocking T cell activation through 4-1BB pathway.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC114552

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of immature T cell proliferation in thymus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 9
Names
tumor necrosis factor receptor superfamily, member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025773.1 → NP_001020944.1  tumor necrosis factor receptor superfamily member 9 precursor

    See identical proteins and their annotated locations for NP_001020944.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097483
    UniProtKB/TrEMBL
    A0A9K3Y716, D4AD93, Q4V895, Q4W8J3
    Related
    ENSRNOP00000052371.3, ENSRNOT00000055506.6
    Conserved Domains (1) summary
    cd13410
    Location:23 → 160
    TNFRSF9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    166664494..166690834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764282.3 → XP_008762504.1  tumor necrosis factor receptor superfamily member 9 isoform X1

    See identical proteins and their annotated locations for XP_008762504.1

    UniProtKB/TrEMBL
    A0A9K3Y716, D4AD93, Q4V895, Q4W8J3
    Conserved Domains (1) summary
    cd13410
    Location:23 → 160
    TNFRSF9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137

  2. XM_039110648.2 → XP_038966576.1  tumor necrosis factor receptor superfamily member 9 isoform X2

    Conserved Domains (2) summary
    cd00185
    Location:23 → 44
    TNFRSF; CRD1 [structural motif]
    cl22855
    Location:23 → 117
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  3. XM_039110649.2 → XP_038966577.1  tumor necrosis factor receptor superfamily member 9 isoform X3

    Conserved Domains (2) summary
    cd00185
    Location:23 → 44
    TNFRSF; CRD1 [structural motif]
    cl22855
    Location:23 → 138
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  4. XM_039110647.2 → XP_038966575.1  tumor necrosis factor receptor superfamily member 9 isoform X1

    UniProtKB/TrEMBL
    A0A9K3Y716, D4AD93, Q4V895, Q4W8J3
    Conserved Domains (1) summary
    cd13410
    Location:23 → 160
    TNFRSF9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137

  5. XM_006239472.5 → XP_006239534.1  tumor necrosis factor receptor superfamily member 9 isoform X1

    See identical proteins and their annotated locations for XP_006239534.1

    UniProtKB/TrEMBL
    A0A9K3Y716, D4AD93, Q4V895, Q4W8J3
    Conserved Domains (1) summary
    cd13410
    Location:23 → 160
    TNFRSF9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137
Nucleotide Protein Strain
Heading Accession and Version

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